57039-63-1

Basic information

• Product Name: 1H-Indole, 6-chloro-2-phenyl-
• CAS NO: 57039-63-1
• Molecular Formula: C14H10ClN
• Molecular Weight: 227.693
• Mol File: 57039-63-1.mol
• Article Data: 51

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 6-chloro-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 6-chloro-2-phenyl-(57039-63-1)
• EPA Substance Registry System: 1H-Indole, 6-chloro-2-phenyl-(57039-63-1)

Safety Data

• Hazardous Substances Data: 57039-63-1(Hazardous Substances Data)

Usage

Structure

A chlorinated derivative of indole, a heterocyclic compound with a chlorine atom at the 6-position and a phenyl group at the 2-position.

Occurrence

Commonly found in nature and used in the synthesis of pharmaceuticals and other organic compounds.

Unique properties

The addition of a chlorine atom to the 6-position of the indole ring gives this compound unique properties, making it useful for various chemical reactions and applications.

Importance

An important building block in organic synthesis.

Potential applications

Has potential for use in the development of new drugs and materials.

Upstream product

• 104683-06-9 1-(6-chloro-2-phenyl-1H-indol-1-yl)ethan-1-one 
• 14091-36-2 N-(5-chloro-2-iodophenyl)acetamide 
• 536-74-3 phenylacetylene 
• 17422-33-2 6-chloroindole 
• 98-80-6 phenylboronic acid 
• 1181455-12-8 C₁₄H₁₂ClN₃ 
• 1449516-98-6 C₁₅H₁₀BrClN₂ 
• 65697-42-9 1-(3-chlorophenyl)-1H-1,2,3,4-tetrazole 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 613-94-5 benzoic acid hydrazide 
• 108-42-9 3-chloro-aniline 
• 6828-35-9 5-chloro-2-iodoaniline 
• 960608-47-3 5-chloro-2-(phenylethynyl) aniline 
• 98-86-2 acetophenone 

Downstream Products

• 7033-52-5 7-chloro-2-phenyl-4H-benzo[d][1,3]oxazin-4-one 
• 19407-50-2 2-benzamido-4-chlorobenzoic acid 
• 606145-75-9 N-(5-chloro-2-cyanophenyl)benzamide 
• 1181455-25-3 6-chloro-2-phenylindoline 

Relevant articles and documents

Regioselective mercury(I)/palladium(II)-catalyzed single-step approach for the synthesis of imines and 2-substituted indoles

An efficient synthesis of ketimines was achieved through a regioselective Hg(I)-catalyzed hydroamination of terminal acetylenes in the presence of anilines. The Pd(II)-catalyzed cycliza-tion of these imines into the 2-substituted indoles was satisfactorily carried out by a C-H acti-vation. In a single-step approach, a variety of 2-substituted indoles were also generated via a Hg(I)/Pd(II)-catalyzed, one-pot, two-step process, starting from anilines and terminal acetylenes. The arylacetylenes proved to be more effective than the alkyl derivatives.

B(C6F5)3-Catalyzed Electron Donor-Acceptor Complex-Mediated Aerobic Sulfenylation of Indoles under Visible-Light Conditions

An efficient B(C6F5)3-catalyzed aerobic oxidative C-S cross-coupling reaction of thiophenol with indoles was developed, affording a wide range of diaryl sulfides in good yields. An electron donor-acceptor complex between B(C6F5)3 and indoles was formed, facilitating the photoinduced single-electron transfer (SET) from indole substrates to the B(C6F5)3 catalyst. This protocol demonstrates a new reaction model using B(C6F5)3 as a single-electron oxidant.

Pd-Catalyzed Reductive Cyclization of Nitroarenes with CO2 as the CO Source

A reductive amination process that constructs indoles, carbazoles or benzimidazoles from nitroarenes – irrespective of their electronic or steric nature – was developed that uses CO2 as the source of CO. The process is robust, tolerating common gaseous components of flue gas (H2S, SO2, NO and H2O) without adversely affecting the reductive cyclization.