570409-63-1Relevant academic research and scientific papers
The design of 8,8-dimethyl[1,6]naphthyridines as potential anticonvulsant agents
Austin, Nigel E.,Hadley, Michael S.,Harling, John D.,Harrington, Frank P.,Macdonald, Gregor J.,Mitchell, Darren J.,Riley, Graham J.,Stean, Tania O.,Stemp, Geoffrey,Stratton, Sharon C.,Thompson, Mervyn,Upton, Neil
, p. 1627 - 1629 (2003)
Starting from a series of 7-linked tetrahydroisoquinoline derivatives, as exemplified by SB-270664, a new series of 8,8-dimethylnaphthyridine compounds has been identified. SAR studies around these attractive leads have provided compounds such as 12 which display excellent anticonvulsant activity and an encouraging pharmacokinetic profile in vivo.
COMPOUNDS AND METHODS OF USE
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Page/Page column 104, (2010/11/27)
Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
