Bioorganic and Medicinal Chemistry Letters p. 1627 - 1629 (2003)
Update date:2022-08-03
Topics:
Austin, Nigel E.
Hadley, Michael S.
Harling, John D.
Harrington, Frank P.
Macdonald, Gregor J.
Mitchell, Darren J.
Riley, Graham J.
Stean, Tania O.
Stemp, Geoffrey
Stratton, Sharon C.
Thompson, Mervyn
Upton, Neil
Starting from a series of 7-linked tetrahydroisoquinoline derivatives, as exemplified by SB-270664, a new series of 8,8-dimethylnaphthyridine compounds has been identified. SAR studies around these attractive leads have provided compounds such as 12 which display excellent anticonvulsant activity and an encouraging pharmacokinetic profile in vivo.
View MoreZhejiang Golden-Shell Pharmaceutical Co.,Ltd.
Contact:+86-576-87501888 / 87501988
Address:No.89 Zhongxing Road. Li'ao, Yuhuan, Zhejiang, China
Huaian Double Win Chemicals Co.,Ltd.
Contact:+86-13511538872
Address:Blk 43,Greenland Century Town,Huaian District, Huaian City,Jiangsu Province,China
website:http://www.cartoonchem.com/
Contact:+86-25-58074918
Address:Room 2109, RuiHua Business Center,315 South ZhongShan Road, Nanjing 210001, China
Hangzhou Fortune Biopharm Co.,LTD.
website:http://www.ftpharm.com
Contact:86-571-87621708
Address:279 Zixuan Road,Xihu District,Hangzhou,Zhejiang(310030),China.
Nanjing Chemical Material Corp.(NCMC)
website:http://www.njchemm.com
Contact:0086-25-83172879
Address:B12 Technology and Innovation Building, Nanjing Tech University, No.5 New Model Road
Doi:10.1016/S0022-1139(00)85311-7
(1975)Doi:10.1016/S0968-0896(00)00198-X
(2000)Doi:10.1016/S0022-328X(00)94145-7
(1975)Doi:10.1021/jm00322a022
(1966)Doi:10.1021/ja00386a063
(1982)Doi:10.1039/c39740000974
(1974)