57054-92-9

Basic information

• Product Name: 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE
• Synonyms: 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE;Pyrimidine, 5-bromo-2-chloro-4-methoxy-;5-BroMo-2-chloro-4-Methox...;2-chloro-5-broMo-4-MethoxypyriMidine;5-Bromo-2-chloro-4-methoxy-1,3-diazine, 5-Bromo-2-chloropyrimidin-4-yl methyl ether;5-Bromo-2-chloro-4-methoxypyrimidine, >=98%
• CAS NO: 57054-92-9
• Molecular Formula: C₅H₄BrClN₂O
• Molecular Weight: 223.46
• Product Categories: Building Blocks;Pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 57054-92-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: 73-75 °C(Solv: hexane (110-54-3))
• Boiling Point: 323.6 °C at 760 mmHg
• Flash Point: 149.5 °C
• Appearance: /
• Density: 1.745 g/cm³
• Vapor Pressure: 0.00049mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -1.35±0.29(Predicted)
• CAS DataBase Reference: 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE(57054-92-9)
• EPA Substance Registry System: 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE(57054-92-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 57054-92-9(Hazardous Substances Data)

Usage

Description

5-Bromo-2-chloro-4-methoxypyrimidine is a halogenated heterocyclic compound that serves as a versatile building block in the chemical synthesis of various halogenated heterocycles. Its unique structure, featuring a pyrimidine core with a bromine, chlorine, and methoxy group, allows for a wide range of applications in different industries.

Uses

Used in Pharmaceutical Industry:
5-Bromo-2-chloro-4-methoxypyrimidine is used as an intermediate in the synthesis of pharmaceutical compounds for the development of new drugs. Its halogenated structure allows for the creation of novel therapeutic agents with improved pharmacological properties, such as enhanced solubility, stability, and bioavailability.
Used in Agrochemical Industry:
In the agrochemical industry, 5-bromo-2-chloro-4-methoxypyrimidine is used as a key intermediate in the synthesis of halogenated heterocycles with pesticidal properties. These compounds can be used to develop new pesticides with increased efficacy and selectivity, as well as reduced environmental impact.
Used in Dye and Pigment Industry:
5-Bromo-2-chloro-4-methoxypyrimidine is used as a building block in the synthesis of halogenated dyes and pigments. Its unique chromophore structure allows for the development of new dyes with improved colorfastness, brightness, and stability, making them suitable for various applications, such as textiles, plastics, and printing inks.
Used in Material Science:
In material science, 5-bromo-2-chloro-4-methoxypyrimidine is used as a precursor for the synthesis of novel halogenated materials with unique electronic, optical, and magnetic properties. These materials can be employed in various high-tech applications, such as organic light-emitting diodes (OLEDs), photovoltaic cells, and sensors.
Used in Research and Development:
5-Bromo-2-chloro-4-methoxypyrimidine is used as a research compound in academic and industrial laboratories for the investigation of new synthetic routes, reaction mechanisms, and the development of innovative applications in various fields. Its unique structure and reactivity make it an attractive target for chemists and material scientists working on the design and synthesis of new functional materials and compounds.

InChI:InChI=1/C5H4BrClN2O/c1-10-4-3(6)2-8-5(7)9-4/h2H,1H3

Upstream product

• 36082-50-5 2,4-dichloro-5-bromopyrimidine 
• 124-41-4 sodium methylate 

Downstream Products

• 142451-94-3 (2-chloro-4-methoxy-5-pyrimidinyl)-2-methoxyphenylmethanol 
• 36082-45-8 5-bromo-4-methoxypyrimidine-2-ylamine 
• 1448868-19-6 5-[6-(4-chloro-phenyl)-2-(2-dimethylamino-4-methoxy-pyrimidin-5-yl)-1-isopropyl-4-oxo-4,6-dihydro-1H-pyrrolo[3,4-d]imidazol-5-yl]-1,3-dimethyl-1H-pyrimidine-2,4-dione 
• 1448867-99-9 4-[(S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-2-(2-dimethylamino-4-methoxy-pyrimidin-5-yl)-3-isopropyl-6-oxo-3,4,5,6-tetrahydro-pyrrolo[3,4-d]imidazol-4-yl]-benzonitrile 
• 1448868-00-5 4-[(R)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-2-(2-dimethylamino-4-methoxy-pyrimidin-5-yl)-3-isopropyl-6-oxo-3,4,5,6-tetrahydro-pyrrolo[3,4-d]imidazol-4-yl]-benzonitrile 
• 1448871-37-1 5-[5-chloro-1-(4-methoxy-benzyl)-6-oxo-1,6-dihydro-pyridin-3-yl]-6-(4-chloro-phenyl)-2-(2-dimethylamino-4-methoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1448867-39-7 4-[5-(5-chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-2-(2-dimethylamino-4-methoxy-pyrimidin-5-yl)-3-isopropyl-6-oxo-3,4,5,6-tetrahydro-pyrrolo[3,4-d]imidazol-4-yl] benzonitrile 
• 1448867-00-2 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-2-[2-(3-hydroxy-azetidin-1-yl)-4-methoxy-pyrimidin-5-yl]-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 

Relevant articles and documents

PYRIMIDONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS

The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).

PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION

The compounds of Formula Ib, Formula Ia, and Formula I are described herein along with their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof. The process of preparation of the compounds of Formula Ib, Formula Ia, and Formula I is also described. The compounds described herein, their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof are 2-(benzyloxy)pyrimidine derivatives that are inhibitors of PD-1/PD-L1 activation.

GLP-1 RECEPTOR MODULATORS

Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where "^^^^" represents either or both the R and S form of the compound) (I) where A, B, C, Y1, Y2, Z, R1, R2, R3, R4, R5, W1, n, p and q are as defined herein.