5707-11-9

Basic information

• Product Name: 3,5-Dimethyl-2,6-diphenylpiperidin-4-one
• Synonyms: 3,5-Dimethyl-2,6-diphenylpiperidin-4-one
• CAS NO: 5707-11-9
• Molecular Formula: C₁₉H₂₁NO
• Molecular Weight: 279.38
• Mol File: 5707-11-9.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 425.1°Cat760mmHg
• Flash Point: 146°C
• Appearance: /
• Density: 1.045g/cm³
• Vapor Pressure: 1.96E-07mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 3,5-Dimethyl-2,6-diphenylpiperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dimethyl-2,6-diphenylpiperidin-4-one(5707-11-9)
• EPA Substance Registry System: 3,5-Dimethyl-2,6-diphenylpiperidin-4-one(5707-11-9)

Safety Data

• Hazardous Substances Data: 5707-11-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H21NO/c1-13-17(15-9-5-3-6-10-15)20-18(14(2)19(13)21)16-11-7-4-8-12-16/h3-14,17-18,20H,1-2H3

Upstream product

• 631-61-8 ammonium acetate 
• 100-52-7 benzaldehyde 
• 96-22-0 pentan-3-one 
• 1147550-11-5 ammonium thiocyanate 
• 59953-67-2 oxime de le dimethyl-3,5 diphenyl-2,6 piperidone-4 
• 74-86-2 acetylene 
• 102081-34-5 t-3,t-5-Dimethyl-N-nitroso-r-2,c-6-diphenylpiperidin-4-one 
• 102449-36-5 1-acetyl-3,5-dimethyl-2,6-diphenyl-piperidin-4-one 
• 87731-83-7 r-2,t-3,t-5,c-6-Tetraphenylpiperidin-4-one 
• 87621-16-7 N-Chloro-3,5-dimethyl-2,6-diphenylpiperidin-4-one 
• 37418-40-9 C₂₀H₂₄N₄O 

Downstream Products

• 677007-17-9 1-hydroxy-3,5-dimethyl-2,6-diphenyl-piperidin-4-one 
• 671213-19-7 N-chloroacetyl-r-2,c-6-diphenyl-t-3,t-5-dimethylpiperidin-4-one 
• 19123-20-7 r⁽²⁾-trans-4-hydroxy-trans-3,5-dimethyl-cis-2,6-diphenylpiperidine 
• 102449-36-5 1-acetyl-3t,5t-dimethyl-2r,6c-diphenyl-piperidin-4-one 
• 20547-29-9 3c,4,5c-trimethyl-2t,6t-diphenyl-piperidin-4r-ol 
• 112818-68-5 1-(2-hydroxy-ethyl)-3t,5t-dimethyl-2r,6c-diphenyl-piperidin-4-one 
• 2403-94-3 3,5-dimethyl-2,6-diphenyl-piperidin-4-ol 
• 1282624-17-2 1-[2-(4-ethoxycarbonylpiperazin-1-yl)acetyl]-3,5-dimethyl-2,6-diphenylpiperidin-4-one 

Relevant articles and documents

Synthesis and characterization of piperidin-4-one derivatives using green solvent

A deep eutectic solvent of glucose-urea was found to be an inexpensive and effective reaction medium in the synthesis of piperidin-4-one derivatives. In this work, 3-methyl-2,6-diphenyl piperidin-4-one (4a), 3,5-dimethyl-2,6-diphenylpiperidin-4-one (4b), 2,6-diphenylpiperidin-4-one (4c), piperidin-4-one (4d), 3,5-dimethylpiperidin-4-one (4e), 3-methyl-2,6-di(2-hydroxyphenyl)piperidin-4-one (4f), 3,5-dimethyl 2,6-di(2-hydroxyphenyl)piperidin-4one (4g) were synthesized using a deep eutectic solvent (DES) of glucose and urea with the percentage composition of 60:40. The yields of these products were 82, 78, 75, 68, 72, 70 and 70 %, respectively. The products obtained were characterized by FT-IR and 1H NMR spectroscopic techniques. A synthesis of piperidin-4-one derivatives by using this green solvent was considered to be new environmentally safe synthetic method.

Cross-linked polystyrene/titanium tetrachloride as a tightly bound complex catalyzed the modified Mannich reaction for the synthesis of piperidin-4-ones

Cross-linked polystyrene beads were prepared, characterized and the resulting polymer carrier was functionalized with titanium tetrachloride (TiCl4)via complexation of polystyrene with TiCl4 to afford the corresponding cross-linked polystyrene-TiCl4 stable complex (PSt/TiCl4)in an one step reaction and characterized by FT-IR, UV, TGA, DSC, XRD, SEM, BET. This tightly bound coordination complex was used as a water tolerant, heterogeneous, recoverable and reusable Lewis acid catalyst for the synthesis of substituted piperidin-4-ones via the modified Mannich multi-component condensation of ketones, aromatic aldehydes, and ammonium acetate in 1:2:1 M ratio under mild conditions. The rate of reactions was found to decrease with an increasing percentage of crosslinking and the mesh size of the copolymer beads. The catalyst is water tolerant, stable and can be easily recovered and reused at least four times without any loss of activity.

Microwave assisted deprotection of heterocyclic semicarbazones by quinolinium flurochromate

The regeneration of semicarbazone from 2,6-diphenyl piperidine-4-one semicarbazone (PPS) and its alkyl substituted derivatives (3, 3 and 5th position) by quinolinium flurochromate (QFC) under microwave irradiation in the presence of montmorillonite K10 clay leads to the formation of ketone in a good yield.