57133-41-2

Basic information

• Product Name: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (2R)-2-hydroxy-2-phenylbutanoate
• Synonyms: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (2R)-2-hydroxy-2-phenylbutanoate
• CAS NO: 57133-41-2
• Molecular Weight: 318.456
• Mol File: 57133-41-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (2R)-2-hydroxy-2-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (2R)-2-hydroxy-2-phenylbutanoate(57133-41-2)
• EPA Substance Registry System: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (2R)-2-hydroxy-2-phenylbutanoate(57133-41-2)

Safety Data

• Hazardous Substances Data: 57133-41-2(Hazardous Substances Data)

Upstream product

• 20229-41-8 l-menthyl phenylglyoxylate 
• 2386-64-3 ethylmagnesium chloride 
• 557-20-0 diethylzinc 
• 925-90-6 ethylmagnesium bromide 
• 6367-60-8 (-)menthyl phenylglyoxalate 
• 2633-75-2 ethylzinc chloride 
• 97-93-8 triethylaluminum 

Downstream Products

• 3966-31-2 (R)-2-hydroxy-2-phenylbutyric acid 
• 24256-91-5 (S)-2-hydroxy-2-phenylbutanoic acid 

Relevant articles and documents

SYNTHESE D'α-HYDROXY ACIDES OPTIQUEMENT ACTIFS

The reaction of chiral MAlR3OR' (M=Li, Na, K; R=Me, Et; OR' from R'OH=(-)N-methylephedrine) with C6H5COCO2(-)-menthyl provide a good synthesis of α-alkyl mandelic acids with enantiomeric excess (e.e.) up to 53 percent.Asymmetric induction due to both the chiral centers of the (-)-menthyl group and the OR' group may be invoked to account for the higher stereoselectivity observed in the reaction.

trans-2-tert-Butylcyclohexanol, ein einfaches, selektivitaetsoptimiertes Cyclohexanol-Auxiliar

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ADDITION DIASTEREOSELECTIVE D'ORGANOZINCIQUES SUR LE PHENYLGLYOXALATE DE (-) MENTHYLE

Organozinc compounds (from Grignard reagents and ZnCl2 or ZnBr2 in diethylether or THF) add selectively to the keto group of (-) menthyl phenylglyoxalate, to give α-substituted (-) menthyl mandelates in high yields and in most cases high levels of asymmet