57152-73-5Relevant academic research and scientific papers
A Passerini/Michael Pathway towards Butyrolactones
Jia, Shuanglong,El Ka?m, Laurent
, p. 6457 - 6464 (2018)
The Passerini adducts of aromatic aldehydes may act as nucleophiles in Michael additions with acrylonitrile. The reaction proceeds together with hydrolysis of the ester. The resulting γ-hydroxynitrile may be cyclized under acidic conditions to afford a three-steps synthesis of γ-butyrolactones from isocyanides.
