57153-51-2Relevant academic research and scientific papers
Synthesis of Pyridazinones through the Copper(I)-Catalyzed Multicomponent Reaction of Aldehydes, Hydrazines, and Alkynylesters
Mantovani, Anderson C.,Goulart, Tales A. C.,Back, Davi F.,Zeni, Gilson
, p. 12663 - 12668 (2014)
The copper-catalyzed multicomponent cyclization reaction, which combined aldehydes, hydrazines, and alkynylesters, was applied in the synthesis of pyridazinones. The reaction was regioselective and gave only six-membered pyridazinones in the complete absence of five-membered pyrazoles or a regioisomeric mixture. During this investigation, the use of 2-halobenzaldehyde as the starting material, under identical reaction conditions, gave 6-(2-ethoxyphenyl)pyridazinones after sequential Michael addition/1,2-addition/Ullmann cross-coupling reactions.
Chemistry of Phosphorus Ylides, 13 Reactions with Phosphacumulenes. VII: Novel Synthesis of Pyridazinones and Pyridazinethiones from the Reaction of Cumulated Phosphorus Ylides with Monohydrazones of α-Diketones, Acenaphthenequinone, and Indantrione
Soliman, Fouad M.,Yakout, El-Sayed M.,Said, Medhat M.
, p. 2162 - 2166 (1994)
The behavior of the reactive phosphacumulenes 2a,b, towards different α-diketone monohydrazones 1, 5, 11, and 13, acenaphthenequinone monohydrazone 8 and indantrione monohydrazone 16 has been studied.In some cases the resulted phosphoranes directly cycliz
A facile approach to N-heterocycles. The reactions of ylide phosphoranes with hydrazones
Ganoub, Neven A.
, p. 143 - 148 (2007/10/03)
The reactions of isatin-β-phenylhydrazone 1 and benzil monophenylhydrazone 2 with some ester-3a,b and keto ylides 3c were studied in details. under different experimental conditions with the aim of evaluating the synthetic potential of this approach for the synthesis of N-heterocyclic systems. Structures of the new compounds were established on the basis of elemental and spectroscopic analyses.
A new and convenient synthesis of 3(2H)-pyridazinones by reacting carbanion of ethyl trimethylsilylacetate with phenylhydrazones
Patel,Vyas,Pandey,Tavares,Fernandes
, p. 1935 - 1940 (2007/10/02)
A one-pot synthesis of 5,6-disubstituted-2-phenyl-3(2H)-pyridazinones 4 is achieved on treatment of carbanion of ethyl trimethylsilylacetate with phenylhydrazones of 1,2-dicarbonyl compounds 1.
Reaction of triethyl phosphonoacetate anion with phenylhydrazones: A new method for the preparation of 3(2H)-pyridazinones
Patel,Vyas,Pandey,Tavares,Fernandes
, p. 1021 - 1026 (2007/10/02)
Various 5,6-disubstituted-2-phenyl-3(2H)-pyridazinones 4 have been synthesised by reacting triethyl phosphonoacetate anion with monophenylhydrazone of 1,2-dicarbonyl compounds 2.
