57160-58-4

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 609-65-4 o-chlorobenzoyl chloride 
• 106-47-8 4-chloro-aniline 
• 5067-90-3 2-chlorobenzoyl isothiocyanate 
• 1072-98-6 5-chloro-2-pyridylamine 
• 333-20-0 potassium thioacyanate 
• 118-91-2 ortho-chlorobenzoic acid 

Relevant academic research and scientific papers

2-Chloro-N-((5-chloropyridine-2-yl)carbamothioyl)benzamide and its Co(II), Ni(II) and Cu(II) metal complexes: Synthesis, characterization, thermal decomposition, electrochemical behavior and antioxidant activity

A novel thiourea derivative 2-chloro-N-((5-chloropyridine-2-yl)carbamothioyl)benzamide ligand (HL) and its transition metal complexes (ML2; M: Co2+, Ni2+ and Cu2+) were synthesized and characterized by elemental analysis, FTIR and 1H-NMR techniques. The HL was also characterized by single-crystal X-ray diffraction method. It crystallizes in the monoclinic space group P 1 21/c 1, with Z?=?4, and unit-cell parameters, a?=?6.7140(15)??, b?=?13.667(3)??, c?=?15.524(4)??. Thermal decomposition of the complexes has been studied by TG/TDA combined system. Cyclic voltammetry technique was utilized to understand the electrochemical behavior of the complexes. Furthermore, the complexes were screened for their antioxidant activities which were measured by using the DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) assays.

Benzoylthioureas: Design, synthesis and antimycobacterial evaluation

Background: New drugs and strategies to treat tuberculosis (TB) are urgently needed. In this context, thiourea derivatives have a wide range of biological activities, including anti-TB. This fact can be illustrated with the structure of isoxyl, an old anti-TB drug, which has a thiourea as a pharmacophore group. Objective: The aim of this study is to describe the synthesis and the antimycobacterial activity of fifty-nine benzoylthioureas derivatives. Methods: Benzoylthiourea derivatives have been synthesized and evaluated for their activity against Mycobacterium tuberculosis using the MABA assay. After that, a structure-activity relationship study of this series of compounds has been performed. Results and Discussion: Nineteen compounds exhibited antimycobacterial activity between 423.1 and 9.6 μM. In general, we observed that the presence of bromine, chlorine and t-Bu group at the para-position in benzene ring plays an important role in the antitubercular activity of Series A. These substituents were fixed at this position in benzene ring and other groups such as Cl, Br, NO2 and OMe were introduced in the benzoyl ring, leading to the derivatives of Series B. In general, Series B was less cytotoxic than Series A, which indicates that the presence of a substituent at benzoyl ring contributes to an improvement in both antimycobacterial activity and toxicity profiles. Conclusion: Compound 4c could be considered a good prototype to be submitted to further structural modifications in the search for new anti-TB drugs, since it is 1.8 times more active than the first line anti-TB drug ethambutol and 0.65 times less active than isoxyl.

Solution-phase microwave assisted parallel synthesis, biological evaluation and in silico docking studies of 2-chlorobenzoyl thioureas derivatives

An efficient and facile microwave-assisted solution phase parallel synthesis for a 38-member library of N-aroyl-N′-aryl thioureas was accomplished successfully. These analogues (1–38) were synthesized under identical set of conditions. It has been observe

Phase-transfer-catalyzed synthesis of N-aryl-N'-(2-chlorobenzoyl)-thiourea derivatives

Reaction of aromatic amines with 2-chlorobenzoyl chloride and ammonium thiocyanate under the condition of solid-liquid phase-transfer catalysis using polyethylene glycol-400 (PEG-400) as the catalyst yielded N-aryl-N'-(2-chlorobenzoyl)thioureas 3a-3j in g