57161-85-0

Usage

Preparation

Preparation by reaction of epichlorohydrin with 2,4-di-hydroxy-3-propylacetophenone in the presence of, potassium hydroxide in refluxing ethanol (64%); potassium carbonate in boiling 2-butanol for 10 h (62%).

Upstream product

• 40786-69-4 1-(2,4-dihydroxy-3-propylphenyl)ethanone 
• 106-89-8 epichlorohydrin 

Downstream Products

• 91324-96-8 2-<3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy>-6-nitrobenzonitrile 
• 101836-07-1 N-{3-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydroxy-propoxy]-2-propyl-phenyl}-acetamide 
• 118683-85-5 N--N-(trifluoroacetyl)-L-cysteinyl>glycine methyl ester 
• 91541-12-7 4-{4-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydroxy-propylsulfanyl]-3-fluoro-phenyl}-4-oxo-butyric acid methyl ester 
• 117023-93-5 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-2-hydroxy-3-propylphenyl>ethanone hydrochloride 
• 40785-97-5 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid 
• 101835-99-8 N-{3-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydroxy-propoxy]-2-cyano-phenyl}-malonamic acid ethyl ester 
• 91327-53-6 [[3-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-2-cyanophenyl]amino]oxoacetic acid ethyl ester 
• 101835-98-7 N-{3-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydroxy-propoxy]-2-cyano-phenyl}-oxalamic acid 2,2-dimethyl-propyl ester 
• 101836-00-4 N-{3-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydroxy-propoxy]-2-propyl-phenyl}-oxalamic acid ethyl ester 
• 91324-99-1 N-{3-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydroxy-propoxy]-2-cyano-phenyl}-oxalamic acid 
• 91324-97-9 2-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-6-aminobenzonitrile 
• 101836-10-6 1-<4-<3-(3-amino-2-propylphenoxy)-2-hydroxypropoxy>-2-hydroxy-3-propylphenyl>ethanone 
• 118682-94-3 N--L-cysteinyl>glycine 

Relevant academic research and scientific papers

2,4-dihydroxyacetophenone derivatives as antileukotrienics with a multiple activity mechanism

A series of 2,4-dihydroxy-3-propylacetophenone derivatives containing alkylthiobenzoic or arylacetic acid moiety was prepared. The antileukotrienic activity of the substances was assessed in terms of inhibition of the biosynthesis of LTB4 and b

Substituted dihydrobenzopyran-2-carboxylates

The invention relates to substituted dihydrobenzopyrans carboxylates of the formula: STR1 wherein A is a methylene chain having 1-10 carbon atoms, inclusive, optionally substituted by hydroxy; wherein V is: (a) hydrogen; (b) hydroxy; (c) =O; or (d) R6 CH2 O--; wherein R1 is: (a) --COCH3 ; (b) --CHOHCH3 ; (c) --C2 H5 ; (d) -hydrogen; or (e) --COOC2 H5 wherein R2 is: (a) -hydrogen; (b) -hydroxy; or (c) R12 CH2 CO2 --; wherein R3, R4, R6, R7, R8, R9, R10, R11 and R12 each of which may be the same or different, are: (a) hydrogen; (b) lower-alkyl having 1-6 carbon atoms inclusive; or (c) allyl; wherein R5 is: (a) hydrogen; or (b) R7 CH2 C(O)--; wherein R13 is hydrogen, hydroxy, alkoxy of 1 to 6 carbon atoms inclusive, or --OM wherein M is an alkali metal, alkyl of 1 to 6 carbon atoms, inclusive, or NR8≈ R9 R10 R11, or HNR8≈ R9 R10, or the pharmacologically acceptable addition salts thereof, which are useful as leukotriene D4 (LTD4) inhibitors and therefore useful in the treatment of allergies and inflammatory conditions.

Novel benzopyran derivatives

7-[3-(4-Acetyl-3-hydroxy-6-iodo-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid and its pharmaceutically acceptable salts are employed as antagonists of SRS-A (the slow reacting substance of anaphylaxis) in the treatmen