57183-54-7Relevant academic research and scientific papers
Synthesis and antiproliferative evaluation of certain 4-anilino-8-methoxy- 2-phenylquinoline and 4-anilino-8-hydroxy-2-phenylquinoline derivatives
Chen, Yeh-Long,Huang, Chao-Jhieh,Huang, Zun-Yuan,Tseng, Chih-Hua,Chang, Feng-Shuo,Yang, Sheng-Huei,Lin, Shinne-Ren,Tzeng, Cherng-Chyi
, p. 3098 - 3105 (2007/10/03)
The present report describes the synthesis and antiproliferative evaluation of certain 4-anilino-8-methoxy-2-phenylquinoline and 4-anilino-8-hydroxy-2- phenylquinoline derivatives. The antiproliferative activity of 4′-COMe-substituted derivatives decrease
Quinoline derivatives as antitubercular/antibacterial agents
Desai,Desai, Pratibha,Machhi, Dilip,Desai,Patel, Dinesh
, p. 871 - 873 (2007/10/03)
A number of quinoline derivatives of known antibacterial agents have been prepared and tested against the micro-organisms S. coli, S. paratyphi B, S. aureus and in particular against Mycobacterium tuberculosis H37-Rv. It has not been possibfe to establish correlation between antibacterial and antitubercular activities of these compounds. However, the antitubercular effect at MIC of 5 μg/mL against H37Rv shows that many modified compounds are more inhibitory than the parent agents such as 3-aminophenol, sulphamethoxazole, sulphaphenazole, sulphathiazole and monoacetyldapsone; among these the most effective are those with substituents such as 6-methyl, 6-chloro, 6-ethoxy-, or 8-methoxy functions in quinoline moiety.
