210366-41-9

Upstream product

• 57205-09-1 ethyl 6-oxocyclohex-1-enecarboxylate 
• 113893-38-2 ω-trimethylsilylbutynylmagnesium chloride 
• 75-77-4 chloro-trimethyl-silane 
• 41423-29-4 4-iodo-1-butynyltrimethylsilane 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 

Relevant academic research and scientific papers

Synthesis of fused bicyclic rings by tandem radical ring expansion/cyclization: Evaluating competing intramolecular reactions

One- and three-carbon 'Dowd-Beckwith' ring expansions of cyclopentanones and cyclohexanones are generally successful, but tandem expansion/cyclization reactions can be compromised by competing processes. An evaluation of the competition between ring expansion, 1,5-hydrogen transfer, and 6-exo cyclization provides information on how to design successful tandem expansion cyclization sequences.

Synthetic Usefulness of the Cobalt(I)-Mediated Ene Type Reaction for the Diastereoselective Construction of Bicyclo[n.3.0]derivatives

Cobalt(I)-catalyzed cycloisomerization of cyclic ε-acetylenic β-ketoesters 1 led to bicyclo[n.3.0]derivatives 2 in high yield and with a total stereocontrol of two contiguous centers.