57206-73-2

Basic information

• Product Name: 1,3-bis-(4-chloro-benzyl)-thiourea
• CAS NO: 57206-73-2
• Molecular Weight: 325.262
• Mol File: 57206-73-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-bis-(4-chloro-benzyl)-thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis-(4-chloro-benzyl)-thiourea(57206-73-2)
• EPA Substance Registry System: 1,3-bis-(4-chloro-benzyl)-thiourea(57206-73-2)

Safety Data

• Hazardous Substances Data: 57206-73-2(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 104-86-9 4-chlorobenzylamine 
• 3694-45-9 4-chlorobenzylisothiocyanate 

Downstream Products

• 57722-91-5 4-(4-chloro-benzyl)-3-(4-chloro-benzylimino)-3,4-dihydro-1H-benzo[e][1,3]thiazepin-5-one 
• 57722-92-6 2,4-bis-(4-chloro-benzyl)-3-thioxo-2,3,4,5-tetrahydro-benzo[e][1,3]diazepin-1-one 
• 3694-45-9 4-chlorobenzylisothiocyanate 

Relevant articles and documents

New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: Biological evaluation and structure-activity relationships

A series of novel benzoimidazo and N-aryl-5-oxo-imidazo[1,2-b]isoquinoline-10-carbothioamides was developed. All the compounds were evaluated for their in vitro action against the epimastigote form of Trypanosoma cruzi. Four of them showed higher activity than Nifurtimox. Their unspecific cytotoxicity was evaluated using HeLa and L6 cells, being non-toxic at concentrations at least 15 and 200 times higher than that of T. cruzi IC50. To gain insight into the mechanism of action, their DNA binding properties and reactivity with glutathione were studied, and QSAR study was performed.