57229-41-1

Usage

Uses

Used in Research and Development:
N-(9-Hydroxy-9H-fluoren-2-yl)acetamide is used as a research compound for studying the mechanism of liver carcinogenesis. Its role in the activation of carcinogens and formation of mutagens provides valuable insights into the processes leading to liver cancer.
Used in Analytical Chemistry:
In the field of analytical chemistry, N-(9-Hydroxy-9H-fluoren-2-yl)acetamide serves as a reference material. It is employed for the identification and quantitation of this specific metabolite, which is crucial in understanding its impact on liver carcinogenesis and potentially developing targeted therapies or preventive measures.
Used in Pharmaceutical Industry:
N-(9-Hydroxy-9H-fluoren-2-yl)acetamide is used as a compound of interest in the pharmaceutical industry. Its properties and interactions with biological systems may lead to the development of new drugs or therapies aimed at preventing or treating liver cancer.
Used in Toxicology:
In toxicology, N-(9-Hydroxy-9H-fluoren-2-yl)acetamide is used as a model compound to study the effects of carcinogens on the liver. Understanding its activation and mutagenicity can help in assessing the risks associated with exposure to similar compounds and inform safety guidelines and regulations.

Safety Profile

Questionable carcinogen withexperimental tumorigenic data. When heated todecomposition it emits toxic fumes of NOx.

InChI:InChI=1/C15H13NO2/c1-9(17)16-10-6-7-12-11-4-2-3-5-13(11)15(18)14(12)8-10/h2-8,15,18H,1H3,(H,16,17)

Upstream product

• 3096-57-9 2-amino-9-fluorenone 
• 33417-27-5 2-amino-9-hydroxyfluorene 
• 108-24-7 acetic anhydride 
• 3096-50-2 2-acetylamino-9-fluorenone 

Downstream Products

• 3096-50-2 2-acetylamino-9-fluorenone 
• 108973-47-3 2-acetamido-9H-fluoren-9-yl acetate 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING DERIVATIVES OF FLUORENE

This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CD34+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.

Oxidative transformation of 2-acetylaminofluorene by a chemical model for cytochrome P450: A water-insoluble porphyrin and tert-butyl hydroperoxide

Oxidation of 2-acetylaminofluorene (AAF), a carcinogen, by a chemical model for cytochrome P450 was investigated to identify an active mutagen and elucidate the oxidation pathway. The oxidation system consisted of a water-insoluble tetrakis(pentafluorophenyl)porphyrinatoiron(III) chloride and tert-butyl hydroperoxide. The mutagen derived from AAF by the chemical model was 2-nitro-9-fluorenone (NO2F{double bond, long}O), which was mutagenic in Salmonella typhimurium TA1538. AAF was oxidized initially at position 9 of the fluorene carbon by the chemical model forming 2-acetylamino-9-fluorenol (AAF-OH), and then oxidized further to 2-acetylamino-9-fluorenone (AAF{double bond, long}O) as a major product. Initial oxidation of the nitrogen formed 2-nitrofluorene (NO2F), and further oxidation yielded 2-nitro-9-fluorenol (NO2F-OH) as a minor product. These products, AAF-OH, AAF{double bond, long}O, NO2F, and NO2F-OH, and their presumable common intermediate, N-hydroxy-2-acetylaminofluorene, were oxidized by the chemical model, and the formation of NO2F{double bond, long}O was determined. These results showed that NO2F{double bond, long}O was the mutagen derived from AAF in the presence of the chemical model and was formed via oxidation of N-OH-AAF, NO2F, and NO2F-OH. These results may lead to a new metabolic pathway of AAF.