57267-45-5

Upstream product

• 96251-91-1 ethyl (E)-7-hydroxyhept-2-enoate 
• 6149-48-0 ethyl 7-hydroxyheptanoate 
• 694-54-2 tetrahydro-2H-2-pyranol 
• 29823-18-5 ethyl 7-bromoheptanoate 
• 603-35-0 triphenylphosphine 

Downstream Products

• 26198-80-1 (Z)-9-((1R,2S,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)non-7-enoic acid 
• 2430-95-7 (Z)-tetradec-7-enoic acid 
• 123-69-3 7-hexadecenoic acid-16-hydroxy-O-lactone 
• 57267-46-6 8-[3'-(4-chlorobenzoyl)-2'-methyl-phenyl]-oct-7-enoic acid 
• 147219-90-7 Benzoic acid (E)-(R)-9-ethoxycarbonyl-1-octyl-non-2-enyl ester 
• 107173-58-0 10-hydroxy-8E-octadecenoic acid 

Relevant academic research and scientific papers

Oxygenated N-Acyl Alanine Methyl Esters (NAMEs) from the Marine Bacterium Roseovarius tolerans EL-164

The marine bacterium Roseovarius tolerans EL-164 (Rhodobacteraceae) can produce unique N-acylalanine methyl esters (NAMEs) besides strucutrally related N-acylhomoserine lactones (AHLs), bacterial signaling compounds widespread in the Rhodobacteraceae. The structures of two unprecedented NAMEs carrying a rare terminally oxidized acyl chain are reported here. The compounds (Z)-N-16-hydroxyhexadec-9-enoyl-l-alanine methyl ester (Z9-16-OH-C16:1-NAME, 3) and (Z)-N-15-carboxypentadec-9-enoyl-l-alanine methyl ester (16COOH-C16:1-NAME, 4) were isolated, and the structures were determined by NMR and MS experiments. Both compounds were synthesized to prove assignments and to test their biological activity. Finally, non-natural, structurally related Z9-3-OH-C16:1-NAME (18) was synthesized to investigate the mass spectroscopy of structurally related NAMEs. Compound 3 showed moderate antibacterial activity against microorganisms such as Bacillus, Streptococcus, Micrococcus, or Mucor strains. In contrast to AHLs, quorum-sensing or quorum-quenching activity was not observed.

Chemoenzymatic preparation of musky macrolactones

Abstract A chemoenzymatic approach to some musk macrolactones has been explored by the optimization of macrolactonization catalyzed by Candida antarctica lipase B (Novozym 435). This fast and high yield optimized methodology represents a large improvement to previously reported results. The methodology was applied to the preparation of 16-hexadecanolide, exaltolide, ambrettolide and (15R)-15-hexadecanolide.

Total synthesis of isoprostanes derived from adrenic acid and EPA

Enantiomerically enriched F2-dihomo-isoprostanes and F 3-isoprostanes have been synthesized. Such compounds are derived from the action of reactive oxygen species on the phospholipid-bound polyunsaturated fatty acids (PUFA), adrenic

SCRIPTAID ISOSTERES AND THEIR USE IN THERAPY

Compounds of the invention are of the formula (I); wherein: … is a double bond and X is C; or … is a single bond and X is N, CH or CQR1; and wherein: n is 1 to 10; R is H or QR1; each R' is independently selected from H and QR1

Development of new methods toward efficient immobilization of chiral catalysts

BINOL moieties are efficiently immobilized onto the surface of a micelle-derived spherical polymer and a monolayer-protected Au cluster (Au-MPC). Ti-BINOLate complexes generated from the BINOL immobilized polymer and Au-MPC are found to promote catalytic

Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors

A series of new, structurally simple trichostatin A (TSA)-like straight chain hydroxamates were prepared and evaluated for their ability to inhibit partially purified human histone deacetylase 1 (HDAC-1). Some of these compounds such as 8m, 8n, 12, and 15

Titanium(III) mediated regiospecific reduction of vinyl epoxides

A highly regiospecific reduction of vinyl epoxides to allyl alcohols with Cp2TiCl is described.