57271-91-7

Basic information

• Product Name: N-butylsalicylamide
• Synonyms: N-butylsalicylamide;Ai3-09485;Benzamide, N-butyl-2-hydroxy-;Einecs 260-659-7
• CAS NO: 57271-91-7
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.2423
• EINECS: 260-659-7
• Mol File: 57271-91-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 329°Cat760mmHg
• Flash Point: 151.3°C
• Appearance: /
• Density: 1.063g/cm³
• Vapor Pressure: 8.16E-06mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: N-butylsalicylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-butylsalicylamide(57271-91-7)
• EPA Substance Registry System: N-butylsalicylamide(57271-91-7)

Safety Data

• Hazardous Substances Data: 57271-91-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H15NO2/c1-2-3-8-12-11(14)9-6-4-5-7-10(9)13/h4-7,13H,2-3,8H2,1H3,(H,12,14)

Upstream product

• 3858-78-4 n-butylamine hydrochloride 
• 119-36-8 methyl salicylate 
• 109-73-9 N-butylamine 
• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 118-55-8 phenyl Salicylate 
• 162936-60-9 3-butyl-3,4-dihydro-2H-1,3-benzoxazine-2,4-dione 
• 111-36-4 n-butyl isocyanide 
• 108-95-2 phenol 

Downstream Products

• 101777-17-7 2-(2,3-dihydroxy-propoxy)-benzoic acid butylamide 
• 143000-16-2 3-Butyl-2-oxo-2-phenyl-2,3-dihydro-2λ⁵-benzo[e][1,3,2]oxazaphosphinin-4-one 
• 143000-08-2 3-Butyl-2-phenyl-2,3-dihydro-benzo[e][1,3,2]oxazaphosphinin-4-one 

Relevant articles and documents

Method for preparing amide compounds

The invention discloses a method for preparing amide compounds. The method comprises the step of subjecting organic carboxylate with a structure represented by a formula (I) shown in the description and an amine compound with a structure represented by a formula (II) shown in the description to a grinding reaction, thereby preparing an amide compound with a structure represented by a formula (III)shown in the description and an alcohol compound with a structure represented by a formula (IV) shown in the description. According to the synthesis method, a heat source is not required to supply heat, an organic solvent is not required to serve as a medium, the operation is simple, the reaction time is short, the aftertreatment is simple, and thus, industrial production is easy to achieve.

Fast synthesis of amides from ethyl salicylate under microwave radiation in a solvent-free system

In this study, amide bond formation, one of the most important reactions in organic chemistry, it was evaluated using ethyl salicylate and ten different primary amines. Under the optimized experimental conditions, i.e. 60 °C, hexane, phenylboronic acid-PBA (15 mol%), boric acid-BA (15 mol%) or without catalyst-WC, using a hot-plate for 24 h, amides were obtained in excellent isolated yields (WC, 77-94% to S-Aa-Ad; PBA, 11-94% to S-Ae-Aj; and BA, 28-90% to S-Ae-Aj). The reaction employing CAL-B also permitted a moderate conversion for the production of amides S-Ae-Aj (3-42%). However, in our efforts to reduce the amide synthesis time (24 h), the reactions were performed in the presence of microwave-MW radiation using a free-solvent system [60 °C, PBA (15 mol%) or WC], which reduced the time of the reaction by 32-fold (45 min) and afforded nine amides (S-Aa-Ah and S-Aj) in 80-99% isolated yield and S-Ai in 23% yield. A cytotoxicity assay demonstrated that the amide S-Ag was capable of inhibiting four human tumor cell lines (MCF-7, HCT116, HepG2, and HL-60) with an IC50 ranging from 8.68 to 17.57 μg mL-1. In this study, MW radiation provided an attractive way for faster reactions, improved yields, and cleaner reactions, as well as the synthesis of amide S-Ag with cytotoxic activity.

AZO COMPOUND, COMPOSITION FOR OPTICAL ALIGNMENT FILM USING SAME, AND METHOD FOR PRODUCING OPTICAL ALIGNMENT FILM

An azo compound of the present invention is represented by the general formula (1): (wherein, R 1 and R 2 each independently represents a hydroxy group, or a polymerizable functional group selected from the group consisting of a (meth)acryloyl group, a (meth)acryloyloxy group, a (meth)acrylamide group, a vinyl group, a vinyloxy group, and a maleimide group; X 1 represents single bond when R 1 is a hydroxy group and represents a linking group represented by -(A 1 -B 1 ) m - when R 1 is a polymerizable functional group; X 2 represents a single bond when R 2 is a hydroxy group and represents a linking group represented by -(A 2 -B 2 ) n - when R 2 is a polymerizable functional group; R 3 and R 4 each independently represents -OR 7 , a hydroxyalkyl group having 1 to 4 carbon atoms, or - CONR 8 R 9 ; and R 5 and R 6 each independently represents a carboxy group, a sulfo group, a nitro group, amino group, or a hydroxy group).