57279-86-4

Upstream product

• 75-36-5 acetyl chloride 
• 52215-24-4 N'-(2,4-dibromophenyl)benzothiohydrazide 

Downstream Products

• 80869-96-1 3-(2,4-dibromophenyl)-2,3-dihydro-5-phenyl-2-thiobenzoylmethylene-1,3,4-thiadiazole 
• 80746-28-7 3-(2,4-dibromophenyl)-2,3-dihydro-5-phenyl-2-propionylmethylene-1,3,4-thiadiazole 
• 80746-22-1 2-acetylmethylene-3-(2,4-dibromophenyl)-2,3-dihydro-5-phenyl-1,3,4-thiadiazole 
• 85921-07-9 3-(2,4-Dibromo-phenyl)-2-[3-(2,4-dibromo-phenyl)-5-phenyl-3H-[1,3,4]thiadiazol-(2Z)-ylidenemethyl]-2-methyl-5-phenyl-2,3-dihydro-[1,3,4]thiadiazole 
• 85921-08-0 3-(2,4-dibromophenyl)-2-(2,4-dinitrobenzylidene)-2,3-dihydro-5-phenyl-1,3,4-thiadiazole 
• 85921-06-8 3-(2,4-dibromophenyl)-2,3-dihydro-2-methoxy-2-methyl-5-phenyl-1,3,4-thiadiazole 
• 80869-95-0 3-(2,4-dibromophenyl)-2,3-dihydro-5-phenyl-2-thioacetylmethylene-1,3,4-thiadiazole 
• 80746-31-2 2-[3-(2,4-Dibromo-phenyl)-5-phenyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-1-phenyl-ethanone 
• 26944-89-8 1-acetyl-6-bromo-3-phenyl-1H-benzo[1,3,4]thiadiazine 

Relevant academic research and scientific papers

Acylation of N'-Arylbenzothiohydrazides and of their N'-Acyl-derivatives; 2-Acylalkylidene-3-aryl-5-phenyl-2H-1,3,4-thiadiazolenes and Related Compounds

Reactions of N'-arylbenzothiohydrazides and of their N-acyl-derivatives with carboxylic anhydrides under various sets of conditions are shown to lead to 2-acylalkylidene-3-aryl-5-phenyl-2H-1,3,4-thiadiazolenes.The probable mechanism of formation of these compounds via the corresponding 2-alkylidenethiadiazolene as intermediate is discussed.

Synthesis and reactions of 1H-4,1,2-benzothiadiazines, and observations on the structure of hydrazonoyl sulphides

Syntheses of 1-acetyl-7- and -8-bromo- and -6,8-dibromo-3-phenyl-4,1,2-benzothiadiazines establish, in conjunction with previous data, the generality of 1H-4,1,2-benzothiadiazine synthesis from appropriately substituted N′-acetyl-N′-arylbenzothiohydrazides. The corresponding 6-nitrobenzothiadiazine is also available by this route, and such cyclizations can proceed by expulsion of a nitro-group, presumably as nitrite ion. These 1H-4,1,2-benzothiadiazines undergo electrophilic substitution at positions 6 and 8, are nucleophilic at position 1, and are oxidizable at position 4 to the corresponding sulphone. X-Ray crystallographic studies of bis-[α-(2,6-dibromophenylhydrazono)benzyl] sulphide confirm the symmetrical structure of hydrazonoyl sulphides.