57296-03-4

Usage

Uses

Used in Bioconjugation Chemistry:
DI(N-Succinimidyl) Oxalate is used as a crosslinking agent for the formation of stable amide bonds between amine-containing molecules. Its high reactivity and selectivity make it an ideal reagent for creating protein-protein, protein-nucleic acid, and protein-small molecule conjugates.
Used in Drug Delivery Systems:
In the pharmaceutical industry, DI(N-Succinimidyl) Oxalate is employed as a key component in the development of drug delivery systems. Its ability to form stable amide bonds allows for the creation of conjugates that can improve the delivery, bioavailability, and therapeutic efficacy of drugs.
Used in Diagnostics:
In the field of diagnostics, DI(N-Succinimidyl) Oxalate is used as a reagent for the development of diagnostic tools and assays. Its ability to form stable conjugates with amine-containing biomolecules enables the creation of highly specific and sensitive diagnostic agents.
Used in Biomaterials:
DI(N-Succinimidyl) Oxalate is also utilized in the development of biomaterials, where its ability to form stable amide bonds is crucial for the creation of biocompatible and functional materials for various applications, including tissue engineering and regenerative medicine.

InChI:InChI=1/C10H8N2O8/c13-5-1-2-6(14)11(5)19-9(17)10(18)20-12-7(15)3-4-8(12)16/h1-4H2

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 3496-11-5 2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate 
• 106086-12-8 N-Oxysuccinimide N'-tert-butyloxycarbonyl-2-phenylthiazolidine-4-carboxylate 
• 3401-36-3 (N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester 
• 3397-32-8 N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester 

Relevant academic research and scientific papers

Preparation method of lithium difluorobisoxalate phosphate solution

The invention provides a preparation method of a lithium difluorobisoxalate phosphate solution, and the method comprises the following steps: 1) reacting N-hydroxysuccinimide and oxalyl chloride in anon-aqueous solvent to obtain a di (N-succinimido) oxalic acid solution; and 2) adding lithium hexafluorophosphate into the di (N-succinimido) oxalic acid solution, and reacting to obtain the lithiumdifluorobisoxalate phosphate solution. According to the preparation method, the obtained solution can be directly used for lithium salt electrolyte materials of lithium ion batteries without further purification, and the method has the advantages of cheap and easily available reaction raw materials, simple operation, environmental friendliness of byproducts, and suitability for industrial production.

A Convenient Synthesis of Peptide Using Oxallates

The equimolar reactions of N-protected amino acids , amino acids or amino acid esters with oxallates (1a-1e) having active ester groups in the presence of pyridine in acetonitrile afforded the corresponding dipeptides via active esters in good yields.

Chemiluminescence

Novel O-oxalylhydroxyl-amine compositions of matter and reactions and to the direct generation of light from chemical energy employing such compositions. By "light" as referred to herein is meant electromagnetic radiation at wavelengths falling between about 350 mμ and 800 mμ. Disclosed compounds include diphthalimide oxalate, disuccinimido oxalate, and dimaleimido oxalate.