57297-29-7

Usage

Chemical Properties

white to light yellow crystal powde

InChI:InChI=1/C4H8N2/c5-4(6)3-1-2-3/h3H,1-2H2,(H3,5,6)/p+1

Upstream product

• 5500-21-0 cyclopropropanecarbonitrile 
• 63190-44-3 cyclopropanecarboximidic Acid Ethyl Ester Hydrochloride 

Downstream Products

• 945955-11-3 2-cyclopropyl-6-isobutylpyrimidine-4-ol 
• 16405-79-1 2-cyclopropyl-1H-benzo[d]imidazole 
• 221548-37-4 2-cyclopropyl-5-methyl-1H-benzimidazole 
• 459796-19-1 2-cyclopropylquinazolin-4(3H)-one 
• 1234334-06-5 (Z)-4-benzylidene-2-cyclopropyl-4,5-dihydro-1H-imidazol-5-one 
• 1234334-15-6 (Z)-4-(4-chlorobenzylidene)-2-cyclopropyl-4,5-dihydro-1H-imidazol-5-one 
• 1234334-12-3 (Z)-2-cyclopropyl-4-(4-methoxybenzylidene)-4,5-dihydro-1H-imidazol-5-one 
• 1234334-09-8 (Z)-2-cyclopropyl-4-(4-methylbenzylidene)-4,5-dihydro-1H-imidazol-5-one 
• 1242441-13-9 4-(4-bromophenyl)-2-cyclopropyl-1H-imidazole 
• 911635-51-3 t-butyl 2-cyclopropyl-4-(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate 
• 1258306-07-8 2-cyclopropyl-6-(2-phenylethyl)-pyrimidin-4-ol 
• 1258306-15-8 6-cyclohexyl-2-cyclopropylpyrimidin-4-ol 
• 1318210-21-7 C₁₈H₂₇N₃O₃ 
• 1353053-34-5 (R)-N-(1-(2-cyclopropyl-1H-imidazol-5-yl)heptyl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Discovery of the bifunctional modulator of angiotensin II type 1 receptor (AT1R) and PPARγ derived from the AT1R antagonist, Fimasartan

Inspired by the well-known PPARγ partial agonism of angiotensin II type 1 receptor (AT1R) antagonists exemplified by an antihypertensive drug, Telmisartan, efforts to identify compounds with the dual activities have been pursued in order to control the two major metabolic disorders, hypertension and hyperglycemia simultaneously. Lead compound 18 derived from the AT1R antagonist, Fimasartan, has successfully presented the possibility to control the medical conditions by a single molecule.

SUBSTITUTED TRIAZOLOPYRIMIDINES AS PDE8 INHIBITORS

Compounds of Formula (I): wherein R1 , R2, R3, R4, and R5 are as defined herein, are disclosed.

PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES

The present invention relates to substituted pyrimidine derivatives, as well as N- oxides thereof and agriculturally acceptable salts thereof, and their use to control undesired plant growth, in particular in crops of useful plants. The invention extends to herbicidal compositions comprising such compounds, N-oxides and/or salts as well as mixtures of the same with one or more further active ingredient (such as, for example, an herbicide, fungicide, insecticide and/or plant growth regulator) and/or a safener. The invention further relates to intermediates useful in the preparation of such compounds, and to processes for their preparation.

CHEMICAL COMPOUNDS

The present invention relates to substituted pyrimidine derivatives of as well as N-oxides and agriculturally acceptable salts thereof, and their use to control undesired plant growth, in particular in crops of useful plants. The invention extends to herbicidal compositions comprising such compounds, N-oxides and/or salts as well as mixtures of the same with one or more further active ingredient (such as, for example, an herbicide, fungicide, insecticide and/or plant growth regulator) and/or a safener.

METHOD FOR PREPARING SUBSTITUTED PYRIMIDINES

Disclosed a method for preparing a ester (Formula I) wherein R1 is cyclopropyl, 4-chlorophenyl or 4-bromophenyl; and R2 is C1-C14 alkyl; comprising contacting acetal (Formula II) with a persulfate oxidant in the presence of a strong sulfur- or phosphorus-containing mineral acid and an oxidation resistant solvent.

METHOD FOR PREPARATION OF OPTIONALLY 2-SUBSTITUTED 1,6-DIHYDRO-6-OXO-4-PYRIMIDINECARBOXYLIC ACIDS

A new method for the preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4 pyrimidinecarboxylic acid compounds of formula (1) is disclosed wherein R1 is H or an optionally substituted carbon moiety. Also disclosed is the method comprising additional steps to prepare optionally substituted 4 pyrimidine-carboxylic acids and esters using the compound of formula (1) as an intermediate.

Novel heterocycles 3

The invention relates to 7-(4-tert butyl-cyclohexyl)-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

Pyrimidine derivatives

This invention provides novel insecticidally and acaricidally active pyrimidine derivatives of formula (I): and stereoisomers thereof, wherein, R1 is selected from alkyl; alkenyl; alkynyl; haloalkyl; haloalkenyl; and cycloalkyl optionally substituted by a