573-46-6

Basic information

• Product Name: 2-BROMO-4'-FLUOROBENZOPHENONE
• Synonyms: 2-BROMO-4'-FLUOROBENZOPHENONE;UKRORGSYN-BB BBV-5117260;(2-broMophenyl)(4-fluorophenyl)Methanone
• CAS NO: 573-46-6
• Molecular Formula: C₁₃H₈BrFO
• Molecular Weight: 279.1
• Mol File: 573-46-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 352.2°C at 760 mmHg
• Flash Point: 166.8°C
• Appearance: /
• Density: 1.485g/cm³
• Vapor Pressure: 3.89E-05mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 2-BROMO-4'-FLUOROBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4'-FLUOROBENZOPHENONE(573-46-6)
• EPA Substance Registry System: 2-BROMO-4'-FLUOROBENZOPHENONE(573-46-6)

Safety Data

• Hazardous Substances Data: 573-46-6(Hazardous Substances Data)

Usage

General Description

2-Bromo-4'-fluorobenzophenone is a chemical compound with the molecular formula C13H8BrFO. It is a white to off-white crystalline powder that is commonly used in organic synthesis and pharmaceutical research. 2-BROMO-4'-FLUOROBENZOPHENONE is classified as a benzophenone derivative, which is a type of aromatic ketone. 2-Bromo-4'-fluorobenzophenone is known for its unique chemical properties, including its high level of reactivity and its ability to undergo various types of chemical reactions. It is commonly used as a building block in the synthesis of other organic compounds and is also used as a starting material for the production of pharmaceutical drugs and agrochemicals. Additionally, this compound is also used as a photoinitiator in the production of photopolymers and in the formulation of UV-curable resins for coatings and adhesives.

InChI:InChI=1/C13H8BrFO/c14-12-4-2-1-3-11(12)13(16)9-5-7-10(15)8-6-9/h1-8H

Upstream product

• 583-55-1 1-Bromo-2-iodobenzene 
• 201230-82-2 carbon monoxide 
• 1765-93-1 4-fluoroboronic acid 
• 88-65-3 2-bromobenzoic-acid 
• 899425-05-9 2-bromo-N-methoxy-N-methylbenzamide 
• 352-13-6 4-flourophenylmagnesium bromide 
• 6630-33-7 ortho-bromobenzaldehyde 
• 59142-67-5 (2-bromophenyl)(4-fluorophenyl)methanol 
• 2042-37-7 o-cyanobromobenzene 

Downstream Products

• 388-30-7 butyl 2-(4-fluorobenzoyl)benzoate 
• 1186678-00-1 (E)-1-bromo-2-[1-(4-fluorophenyl)-2-methoxyethenyl]benzene 
• 68355-79-3 1-bromo-2-(4-fluorobenzyl)benzene 
• 438-61-9 2,2'-bis-(4-fluoro-benzoyl)-biphenyl 

Relevant articles and documents

Divergent Access to Benzocycles through Copper-Catalyzed Borylative Cyclizations

A copper-catalyzed chemodivergent approach to five- and six-membered benzocycles from dienyl arenes tethered with a ketone has been developed. Through proper choice of coordinating ligands and catalytic conditions, copper-catalyzed borylative cyclization of a single dienyl arene can be diverted to two different pathways, leading to indanols and dihydronaphthalenols with high stereoselectivity. The chiral bidentate bisphosphine ligand (S,S)-Ph-BPE was optimal for asymmetric copper-allyl addition to a tethered ketone via a boat-like transition state, whereas NHC ligands led to boro-allyl addition producing indanols with high diastereoselectivity. (Figure presented.).

Chiral electron-rich PNP ligand with a phospholane motif: Structural features and application in asymmetric hydrogenation

Despite the remarkable reactivity that was achieved by a series of transition-metal catalysts with a PNP type ligand, the electron-rich chiral PNP ligands have still been rarely reported because of the difficulties in synthesis and the nature of air-sensitivity. Herein, we report a novel chiral PNP ligand (Heng-PNP) with both a rigid backbone and a bulky tert-butyl group on the phospholane motif. We successfully obtained its divalent iron complex. The chiral environment of its Ir(III) complex was also discussed with quadrant analysis. This tridentate ligand was applied in iridium-catalyzed asymmetric hydrogenation of challenging diaryl ketones: up to 98% ee and 500 TON are achieved. Computational study showed that the twist of conjugate aryl group in the substrate (induced by the special chiral pocket of Ir/Heng-PNP complex) leads to the energy difference in the enantiodetermining step.

Synthesis of Substituted Naphthalenes by 1,4-Palladium Migration Involved Annulation with Internal Alkynes

The palladium catalyzed annulation of 1-bromo-2-vinylbenzene derivatives with internal alkynes was realized for the efficient synthesis of substituted naphthalenes. A controllable aryl to vinylic 1,4-palladium migration process is the key for success.