57328-25-3

Upstream product

• 1079-66-9 chloro-diphenylphosphine 
• 76-05-1 trifluoroacetic acid 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 14744-12-8 diphenyl ethylphosphonite 
• 75-89-8 2,2,2-trifluoroethanol 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 4559-70-0 Diphenylphosphine oxide 
• 1733-55-7 ethyl diphenylphosphinate 
• 719-80-2 Ethyl diphenylphosphinite 

Downstream Products

• 1166111-41-6 (E,E)-1,4-dibromo-2,5-bis(3,3,3-trifluoroprop-1-enyl)benzene 
• 871224-05-4 2-(1,3-dihydro-2H-benzimidazol-2-ylidene)-1-(3-fluorophenyl)-3-{3-[(1Z)-3,3,3-trifluoroprop-1-en-1-yl]phenyl}propane-1,3-dione 
• 908247-55-2 (E)-2-chloro-4-(3,3,3-trifluoroprop-1-enyl)benzoic acid 
• 908248-30-6 (E)-tert-butyl 2-fluoro-4-(3,3,3-trifluoroprop-1-enyl)benzoate 
• 908247-96-1 (Z)-tert-butyl 2-fluoro-4-(3,3,3-trifluoroprop-1-enyl)benzoate 
• 78622-58-9 trans-β-(trifluoromethyl)-4-(methoxycarbonyl)-styrene 
• 1415969-28-6 C₅₂H₆₈F₃N₅O₁₁ 
• 950-03-8 4-(3,3,3-trifluoropropenyl)benzoic acid: 
• 647855-51-4 5-bromo-1,2-dimethoxy-3-(3,3,3-trifluoropropenyl)benzene 
• 433941-71-0 (E)-4-(3,3,3-trifluoroprop-1-enyl)benzenecarbonitrile 
• 78622-55-6 (E)-1-(3,3,3-trifluoroprop-1-enyl)-4-methoxybenzene 
• 705-89-5 (E)-3,3,3-trifluoro-1-phenylpropene 
• 74031-42-8 (Z)-(3,3,3-trifluoroprop-1-en-1-yl)benzene 

Relevant academic research and scientific papers

Copper-Catalyzed Insertion into Heteroatom-Hydrogen Bonds with Trifluorodiazoalkanes

Copper-catalyzed Si-H, B-H, P-H, S-H, and N-H insertion reactions of 2,2,2-trifluoro-1-diazoethane and 1-aryl 2,2,2-trifluorodiazoethanes generated a large number of new fluorine-containing chemical entities for medicinal chemists. With selected Si-H and

Correlation of the rates of solvolysis of chlorodiphenylphosphine using the extended grunwald-winstein equation

Specific rates of solvolysis involving displacement of chloride from the trivalent phosphorus of chlorodiphenylphosphine (Ph2PCl, 1) are reported for ethanol, methanol, and aqueous binary mixtures incorporating ethanol, methanol, acetone, 2,2,2-trifluoroethanol (TFE), and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP). The 25 solvents give an extended Grunwald-Winstein correlation with an l value of 1.25 0.09, m value of 0.46 0.06, and correlation coefficient (R) of 0.954. The reactions in aqueous acetone were unusually fast, and these data points lie above the plot. Specific rate values are also reported for TFE-ethanol mixtures. For five representative solvents, values were obtained at three additional temperatures and activation parameters are presented. Rather low enthalpies of activation (8.4 to 11.8 kcal mol-1) are accompanied by very negative entropies of activation (-33 to -46 cal mol-1K-1). The kinetic features observed are consistent with an SN2 reaction incorporating appreciable bond formation and bond breaking at the transition state, and they are very similar to those previously observed for diphenylphosphinyl chloride (Ph2POCl).

LIQUID CRYSTALLINE COMPOUND, LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL DISPLAY ELEMENT

The invention provides a liquid crystal compound which has stability to heat, light and so forth, shows liquid crystal phases in a wide temperature range, and has a small viscosity, an appropriate optical anisotropy, a large dielectric anisotropy, and an

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

AMIDE DERIVATIVES AS ION CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME

Abstract of the Disclosure Compounds are disclosed that have a formula represented by Formula I herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals in

AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME

Compounds are disclosed that have a formula represented by the following: Formula (I) The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, in

Convenient synthesis of 3,3,3-trifluoropropenyl compounds from aromatic aldehydes by means of the TBAF-mediated horner reaction

A simple synthesis of 3,3,3-trifluoropropenyl compounds by means of the TBAF-mediated Horner reaction is described. The reagent, 2,2,2-trifluoroethyldiphenylphosphine oxide, was readily prepared either by Arbuzov reaction of ethyl diphenylphosphinite with 2,2,2-trifluoroethyl iodide or by treating chlorodiphenylphosphine with trifluoroacetic acid and water. Treatment of the phosphine oxide with aromatic aldehydes in the presence of TBAF at room temperature afforded the corresponding 3,3,3-trifluoropropenyl compounds in good yields. The present method is very convenient for preparing 3,3,3-trifluoropropenyl compounds from aromatic aldehydes in terms of availability of the reagent, operational simplicity, and good yields of the products.

TERTIAERE PHOSPHINOXIDE AUS DIPHENYLCHLORPHOSPHIN UND CARBONSAEUREN

Starting from Diphenylchlorophosphine and mono or dicarboxylic acids, the preparation of diphenylalkylphosphine oxides, in good yields in a simple synthetic procedure is described.