5734-68-9

Basic information

• Product Name: 4,6-DICHLORO-N,N-DIMETHYL-2-PYRIMIDINAMINE
• Synonyms: 4,6-DICHLORO-N,N-DIMETHYL-2-PYRIMIDINAMINE;4,6-dichloro-2-(dimethylamino)pyrimidine;4,6-dichloro-N,N-diMethylpyriMidin-2-aMine
• CAS NO: 5734-68-9
• Molecular Formula: C₆H₇Cl₂N₃
• Molecular Weight: 192.05
• Mol File: 5734-68-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 56-57,5°C
• Boiling Point: 285.1 °C at 760 mmHg
• Flash Point: 126.2 °C
• Appearance: /
• Density: 1.393g/cm³
• Vapor Pressure: 0.00286mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4,6-DICHLORO-N,N-DIMETHYL-2-PYRIMIDINAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLORO-N,N-DIMETHYL-2-PYRIMIDINAMINE(5734-68-9)
• EPA Substance Registry System: 4,6-DICHLORO-N,N-DIMETHYL-2-PYRIMIDINAMINE(5734-68-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5734-68-9(Hazardous Substances Data)

Usage

General Description

4,6-Dichloro-N,N-dimethyl-2-pyrimidinamine is a chemical compound used primarily as a fungicide and herbicide in agriculture. It works by inhibiting the growth of fungi and weeds, making it an effective tool for protecting crops and promoting healthy plant growth. It is also used in some household products for controlling pests and in industrial settings for preserving wood and textile materials. However, it is important to handle this chemical with caution due to its potential toxicity, and it should be used in accordance with safety guidelines and regulations.

InChI:InChI=1/C6H7Cl2N3/c1-11(2)6-9-4(7)3-5(8)10-6/h3H,1-2H3

Upstream product

• 3764-01-0 2,4,6-trichloropyrimidine 
• 124-40-3 dimethyl amine 
• 56-05-3 2-Amino-4,6-dichloropyrimidine 
• 74-88-4 methyl iodide 
• 117290-56-9 2-dimethylamino-1H-pyrimidine-4,6-dione 

Downstream Products

• 13012-26-5 4-chloro-6-methoxy-N,N-dimethylpyrimidin-2-amine 
• 1202-22-8 6-chloro-N₂,N₂,N₄,N₄-tetrapyrimidin-2,4-diamine 
• 1075-39-4 4-Amino-6-chlor-2-dimethylamino-pyrimidin 
• 119222-45-6 4-chloro-2-(N,N-dimethylamino)-6-(2-fluorobenzylamino)-pyrimidine 
• 117077-96-0 (4-benzyloxy-6-chloro-pyrimidin-2-yl)-dimethyl-amine 

Relevant articles and documents

Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors

Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) regulates the proliferation and differentiation of neuronal progenitor cells during brain development. Consequently, DYRK1A has attracted interest as a target for the treatment of neurodegenerative diseases, including Alzheimer's disease (AD) and Down's syndrome. Recently, the inhibition of DYRK1A has been investigated as a potential treatment for diabetes, while DYRK1A's role as a mediator in the cell cycle has garnered interest in oncologic indications. Structure-activity relationship (SAR) analysis in combination with high-resolution X-ray crystallography leads to a series of pyrazolo[1,5-b]pyridazine inhibitors with excellent ligand efficiencies, good physicochemical properties, and a high degree of selectivity over the kinome. Compound 11 exhibited good permeability and cellular activity without P-glycoprotein liability, extending the utility of 11 in an in vivo setting. These pyrazolo[1,5-b]pyridazines are a viable lead series in the discovery of new therapies for the treatment of diseases linked to DYRK1A function.

HETEROCYCLIC SULFONAMIDE DERIVATIVE AND MEDICINE COMPRISING SAME

The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof. The compound has a superior TRPA1 antagonist activity, and can provide a medicament useful for the prophylaxis or treatment of diseases involving TRPA1 antagonist and TRPA1.