13012-26-5

Basic information

• Product Name: N-(4-CHLORO-6-METHOXY-2-PYRIMIDINYL)-N,N-DIMETHYLAMINE
• Synonyms: N-(4-CHLORO-6-METHOXY-2-PYRIMIDINYL)-N,N-DIMETHYLAMINE;2-Pyrimidinamine, 4-chloro-6-methoxy-N,N-dimethyl-;4-CHLORO-6-METHOXY-N,N-DIMETHYLPYRIMIDIN-2-AMINE
• CAS NO: 13012-26-5
• Molecular Formula: C₇H₁₀ClN₃O
• Molecular Weight: 187.63
• Mol File: 13012-26-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 139-142°C
• Boiling Point: 293.7 °C at 760 mmHg
• Flash Point: 131.4 °C
• Appearance: /
• Density: 1.252 g/cm³
• Vapor Pressure: 0.0017mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: 2-8°C
• PKA: 2.36±0.10(Predicted)
• CAS DataBase Reference: N-(4-CHLORO-6-METHOXY-2-PYRIMIDINYL)-N,N-DIMETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-CHLORO-6-METHOXY-2-PYRIMIDINYL)-N,N-DIMETHYLAMINE(13012-26-5)
• EPA Substance Registry System: N-(4-CHLORO-6-METHOXY-2-PYRIMIDINYL)-N,N-DIMETHYLAMINE(13012-26-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 13012-26-5(Hazardous Substances Data)

Usage

General Description

N-(4-chloro-6-methoxy-2-pyrimidinyl)-N,N-dimethylamine is a chemical compound with the molecular formula C8H11ClN4O. It is a dimethylamine salt derivative of 4-chloro-6-methoxy-2-pyrimidinyl, and is commonly used as an agricultural intermediate for the synthesis of various pesticides and herbicides. N-(4-CHLORO-6-METHOXY-2-PYRIMIDINYL)-N,N-DIMETHYLAMINE functions as a selective systemic herbicide, targeting broad-leaved and grassy weeds in crops such as wheat, barley, and oats. It works by inhibiting the enzyme dihydropteroate synthase, which is involved in the production of folic acid in plants. When used properly, N-(4-chloro-6-methoxy-2-pyrimidinyl)-N,N-dimethylamine can effectively control weed growth and improve crop yield.

InChI:InChI=1/C7H10ClN3O/c1-11(2)7-9-5(8)4-6(10-7)12-3/h4H,1-3H3

Upstream product

• 67-56-1 methanol 
• 5734-68-9 4,6-dichloro-N,N-dimethyl-pyrimidin-2-amine 
• 124-41-4 sodium methylate 
• 5734-64-5 2-amino-4-chloro-6-methoxypyrimidine 
• 74-88-4 methyl iodide 

Relevant articles and documents

Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors

Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) regulates the proliferation and differentiation of neuronal progenitor cells during brain development. Consequently, DYRK1A has attracted interest as a target for the treatment of neurodegenerative diseases, including Alzheimer's disease (AD) and Down's syndrome. Recently, the inhibition of DYRK1A has been investigated as a potential treatment for diabetes, while DYRK1A's role as a mediator in the cell cycle has garnered interest in oncologic indications. Structure-activity relationship (SAR) analysis in combination with high-resolution X-ray crystallography leads to a series of pyrazolo[1,5-b]pyridazine inhibitors with excellent ligand efficiencies, good physicochemical properties, and a high degree of selectivity over the kinome. Compound 11 exhibited good permeability and cellular activity without P-glycoprotein liability, extending the utility of 11 in an in vivo setting. These pyrazolo[1,5-b]pyridazines are a viable lead series in the discovery of new therapies for the treatment of diseases linked to DYRK1A function.

(3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING

The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease. (Formula)