57341-12-5

Upstream product

• 108-98-5 thiophenol 
• 1193-82-4 racemic methyl phenyl sulfoxide 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 882-33-7 diphenyldisulfane 
• 130-15-4 [1,4]naphthoquinone 
• 27098-65-3 3-phenylsulfanyl-propionaldehyde 
• 1696-17-9 N,N-diethylbenzamide 
• 80227-71-0 β-thiophenylacrolein 
• 217638-23-8 2-phenylsulfanyl-naphthalene-1,4-diol 

Downstream Products

• 119449-66-0 2-(2-Oxo-cyclobutyl)-3-phenylsulfanyl-[1,4]naphthoquinone 
• 122647-40-9 (1S,4aS,9aS)-9a-Phenylsulfanyl-1-trimethylsilanyloxy-1,4,4a,9a-tetrahydro-anthraquinone 
• 129155-38-0 2-(2-oxocyclohexyl)-3-phenylthio-1,4-naphthoquinone 
• 127636-02-6 2-(3'-chlorophenacyl)-3-phenylthio-1,4-naphthoquinone 
• 918147-32-7 2-(phenyl)-3-(4-methoxyphenyl)sulphanyl-1,4-naphthalenediol 
• 918147-35-0 2-(phenyl)-3-(4-methylphenyl)sulphanyl-1,4-naphthalenediol 
• 130-15-4 [1,4]naphthoquinone 
• 122630-08-4 (4aS,5aR,11aR,12aR)-5a-Phenylsulfanyl-2-trimethylsilanyloxy-4,4a,5a,11a,12,12a-hexahydro-1H-naphthacene-5,6,11-trione 
• 122630-10-8 (4aS,5aR,11aR,12aR)-5a-Phenylsulfanyl-4,4a,5a,11a,12,12a-hexahydro-1H,3H-naphthacene-2,5,6,11-tetraone 
• 122630-06-2 (4aS,9aS)-9a-Phenylsulfanyl-4a,9a-dihydro-4H-anthracene-1,9,10-trione 
• 119449-72-8 2-(1-Bromo-2-oxo-2-phenyl-ethyl)-3-phenylsulfanyl-[1,4]naphthoquinone 
• 62452-63-5 2-phenylnaphtho[2,3-b]furan-4,9-dione 
• 138648-17-6 5-(4-hydroxy-1-oxo-3-phenylsulfinyl-1,2-dihydro-2-naphthylidene)-4-trimethylsiloxytetrahydrofuran-2-one 
• 138648-15-4 (4R*,5R*)-5-(1,4-dioxo-3-phenylsulfanyl-1,4-dihydro-2-naphthyl)-4-trimethylsiloxytetrahydrofuran-2-one 

Relevant academic research and scientific papers

Inhibition of Ca2+-activated and voltage-dependent K+ currents by 2-mercaptophenyl-1,4-naphthoquinone in pituitary GH3 cells: contribution to its antiproliferative effect.

Quinones have been shown to possess antineoplastic activity; however, their effects on ionic currents remain unclear. The effects of 2-mercaptophenyl-1,4-naphthoquinone (2-MPNQ), menadione (MD) and 1,4-naphthoquinone (1,4 NQ) on cell proliferation and ion

Synthesis method of thioether compound containing 1,4-naphthoquinone structure

The invention belongs to the technical field of organic chemical synthesis, and discloses a synthesis method of a thioether compound containing a 1,4-naphthoquinone structure; the thioether compound containing the 1,4-naphthoquinone structure is prepared by carrying out a reaction on a tetralone compound with a sulfoxide compound under the catalytic action of iodine, the reaction temperature is 60-100 DEG C, and the reaction time is 6-24 h. Compared with a synthesis method in the prior art, the method has the advantages that the naphtholone compound which is cheap, easy to obtain, wide in source, stable and low in toxicity and the low-toxicity odorless sulfoxide compound can be used for generating the thioether compound containing the 1,4-naphthoquinone structure through one-step reaction,the requirement for green chemistry is met, the requirement of the method on reaction conditions is low, and the yield of the obtained product is relatively high.

Synthesis of carbazoloquinone derivatives and their antileukemic activity via modulating cellular reactive oxygen species

Carbazoloquinone alkaloids are of great interest as privileged structures for anticancer drug molecules. The purpose of this study was to investigate the structure-activity relationships of carbazoloquinone derivatives as anticancer agents. A series of ca

Silver-Catalyzed Direct Thiolation of Quinones by Activation of Aryl Disulfides to Synthesize Quinonyl Aryl Thioethers

A silver-catalyzed coupling reaction of quinones with aryl disulfides for the synthesis of quinonyl aryl thioethers is described. In the presence of AgOAc (0.2 equiv)/dppp (0.24 equiv) as the catalyst, (NH4)2S2O8/sub

NAPHTHAQUINONE METHYLTRANSFERASE INHIBITORS AND USES THEREOF

Provided herein are compounds of (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, and prodrugs thereof. Also provided are pharmaceutical compositions and methods involving the inventive compounds for the treatment of proliferative diseases (e.g., cancer (e.g., leukemia, breast cancer, melanoma, metastatic cancer) and diseases associated with inappropriate SET8 activity. Also provided are methods for inhibiting SET8 and methods for labelling SET8.

Green synthesis of thiophenyl-1,4-naphthoquinones

Reaction of 1,4-naphthoquinones adsorbed on neutral alumina to thiophenols in ambient conditions gave respective mono thiophenyl 1,4-naphthoquinones regioselectively in quantitative yield. The solvent free synthesis and quantitative conversion makes the process practical method.

Synthesis of benzo[b]naphtho[2,3-d]thiophene-6,11-diones via palladium(II) acetate-mediated cyclization of 3-arylthio-1,4-naphthoquinone

Palladium(II)-mediated oxidative cyclization of 3-arylthio-1,4- naphthoquinone (4) giving biologically important benzo[b]naphtho-[2,3-d] thiophene-6,11-diones (2) has been performed with a stoichiometric amount of palladium(II) acetate in distillated acet

Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents

The synthesis and evaluation of some 2-substituted-1,4-naphthoquinones 2, S-(1,4-naphthoquinon-2-yl)-mercaptoalkanoic acid amides 4, related benzoquinone and naphthoquinone derivatives 6-9 and 2,3-disubstituted 1,4-naphthoquinones 10-11 were carried out.

Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents

A series of 1,4-naphthoquinone derivatives were synthesized and tested for antifungal and antitumor activity against a number of fungal disease causative species and Walker 256 carcinoma cell lines. The results show that the compounds 8a,e and 11b possess

CONDENSATION INDOLE/NAPHTHOQUINONE. SYNTHESE D'UNE NOUVELLE SERIE D'INDOLYL-1,4-NAPHTHOQUINONES

Addition of an indole, which does not have a group at the 3-position, to 1,4-naphthoquinone leads to the expected 2-(3-indolyl)-1,4-naphthoquinone.When the 1,4-naphthoquinone is substituted at the 2-position by an alkyl or aryl group, the 2-substituted 3-(3-indolyl)-1,4-naphthoquinone is easily formed.However, when the 2-substituent of the quinone is functional (OH, OMe, Cl, Br, NC5H10, S-C6H5), in addition to the new series of expected indolylnaphthoquinones, several by-products resulting from elimination of the 2-substituted and/or further reaction of these compounds are formed.The outcome at the reaction appears to be very sensitive to the experimental conditions.