57345-51-4

Usage

InChI:InChI=1/C11H15N5O2/c12-10-9-11(14-4-13-10)16(5-15-9)7-1-6(3-17)8(18)2-7/h4-8,17-18H,1-3H2,(H2,12,13,14)/t6-,7-,8+/m1/s1

Upstream product

• 29783-26-4 cis-4-cyclopentene-1,3-diol 
• 121236-42-8 Acetic acid (1S,2R,3S,4S)-2-acetoxymethyl-4-azido-3-iodomethyl-cyclopentyl ester 
• 121236-40-6 C₁₇H₂₈IN₃O₄ 
• 100018-56-2 (+)-(1S, 2R, 4R)-4-amino-2-(hydroxymethyl)-1-cyclopentanol 
• 121236-47-3 (1S,2R,3S,4S)-4-Azido-2-hydroxymethyl-3-iodo-cyclopentanol 
• 121236-41-7 (1S,2R,3S,4S)-4-Azido-2-hydroxymethyl-3-iodomethyl-cyclopentanol 
• 121312-31-0 (3aS,4R,5S,6aR)-5-(Tetrahydro-pyran-2-yloxy)-4-(tetrahydro-pyran-2-yloxymethyl)-hexahydro-cyclopenta[b]furan-2-one 
• 123240-66-4 4,6-dichloro-5-formamidopyrimidine 
• 121236-37-1 [(1S,2R,3S,5R)-5-Methanesulfonyloxy-3-(tetrahydro-pyran-2-yloxy)-2-(tetrahydro-pyran-2-yloxymethyl)-cyclopentyl]-acetic acid methyl ester 
• 121236-38-2 [(1S,2R,3S,5S)-5-Azido-3-(tetrahydro-pyran-2-yloxy)-2-(tetrahydro-pyran-2-yloxymethyl)-cyclopentyl]-acetic acid methyl ester 
• 121236-39-3 [(1S,2R,3S,5S)-5-Azido-3-(tetrahydro-pyran-2-yloxy)-2-(tetrahydro-pyran-2-yloxymethyl)-cyclopentyl]-acetic acid 
• 121236-45-1 (1S,2R,3S,5S)-3-Acetoxy-2-acetoxymethyl-5-azido-cyclopentanecarboxylic acid 
• 121236-43-9 Acetic acid (1S,2R,3S,4S)-2-acetoxymethyl-4-azido-3-hydroxymethyl-cyclopentyl ester 
• 76704-05-7 <3aS(3aα,4α,5β,6aα)>-(+)-5-hydroxy-4-hydroxymethyl-hexahydro-2H-cyclopentafuran-2-one 

Downstream Products

• 106665-50-3 N-(9-((1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide 
• 204515-54-8 5'-O-DMT-8-oxo-7,8-dihydro-2'-deoxycarbainosine 
• 204515-51-5 8-(Benzyloxy)-2'-deoxyaristeromycin 

Relevant academic research and scientific papers

3'3'-CYCLIC DINUCLEOTIDE ANALOGUE COMPRISING A CYCLOPENTANYL MODIFIED NUCLEOTIDE AS STING MODULATOR

The present disclosure relates to 3'3'-cyclic dinucleotides comprising a carbocyclic nucleotide and derivatives thereof, that can modulate the activity of the STING adaptor protein.

An efficient total synthesis of carbocyclic 2'-deoxyribonucleosides

The present work describes a new and efficient method for the preparation of either racemic or enantiomerically pure carbocyclic 2'-deoxyribonucleosides 1. Key steps are the efficient assembly of the racemic carbocyclic 2'-deoxyribose core (±)-12, its enzymatic resolution, and a new approach to covalently link the purine and pyrimidine bases with the cyclopentane moiety via the cyclic sulfate (+)-19. This total synthesis of enantiomerically pure and racemic carbocyclic 2'-deoxyribonucleosides 1 represents one of the most efficient approaches reported to date. Starting from cyclopentadiene, the four carbocycles corresponding to the naturally occurring 2'-deoxyribonucleosides could be prepared in 12 steps and 9-12% overall yield. For the corresponding racemic compounds, 10 steps were used with overall yields between 22 and 30%.