20763-91-1

Usage

Uses

Used in Pharmaceutical Synthesis:
1,3-Dihydro-2,4-dioxopyrimidine-5-acetic acid is used as a key intermediate for the synthesis of various pharmaceuticals. Its role in creating essential natural products, such as histidine and tryptophan, highlights its importance in developing new drugs and improving existing ones.
Used in Agrochemical Production:
In the agricultural sector, 1,3-Dihydro-2,4-dioxopyrimidine-5-acetic acid is employed as a building block in the development of agrochemicals. Its versatility allows for the creation of compounds that can enhance crop protection and contribute to more efficient and sustainable agricultural practices.
Used in Chemical Industry:
The chemical industry also benefits from the use of 1,3-Dihydro-2,4-dioxopyrimidine-5-acetic acid as a versatile compound in the synthesis of various chemical products. Its ability to be integrated into different chemical structures makes it a valuable component in the development of new materials and technologies.

InChI:InChI=1/C6H6N2O4/c9-4(10)1-3-2-7-6(12)8-5(3)11/h2H,1H2,(H,9,10)(H2,7,8,11,12)

Upstream product

• 57-13-6 urea 
• 5472-38-8 diethyl 2-formylbutanedioate 
• 64-19-7 acetic acid 
• 66-22-8 uracil 
• 29571-39-9 ethyl 2-(4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate 

Downstream Products

• 57346-43-7 5-methoxymethyluracil 
• 917024-99-8 ethyl 2-(2,4-dichloropyrimidin-5-yl)acetate 
• 189069-53-2 N-succinimidyl-2',3',5'-tri-O-benzoyl-5-carboxymethyluridine 
• 189069-54-3 2',3',5'-tri-O-benzoyl-5-[(N-hydroxy)-carboxamidomethyl]uridine 
• 189069-52-1 2',3',5'-tri-O-benzoyl-5-carboxymethyluridine 

Relevant academic research and scientific papers

DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES

The application describes dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.

Linked peptide nucleic acids

Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to the peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.

Peptide nucleic acids

Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be orientated either parallel or antiparallel to each other.

Free Radical Carboxymethylation of Uracils with Benzoyl Peroxide in Acetic Acid

Acetic acid solutions of the uracils and benzoyl peroxide were heated at 80 deg C to give 5-carboxymethyluracils.Similar treatment of caffeine and benzothiazole gave 8-methylcaffeine and 2-methylbenzothiazole, respectively.