5736-96-9

Basic information

• Product Name: 1-Propanone, 1-[4-(hexyloxy)phenyl]-
• CAS NO: 5736-96-9
• Molecular Formula: C15H22O2
• Molecular Weight: 234.338
• Mol File: 5736-96-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-[4-(hexyloxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-[4-(hexyloxy)phenyl]-(5736-96-9)
• EPA Substance Registry System: 1-Propanone, 1-[4-(hexyloxy)phenyl]-(5736-96-9)

Safety Data

• Hazardous Substances Data: 5736-96-9(Hazardous Substances Data)

Usage

Uses

Solvent in various chemical reactions and processes, indicating its applications in the industry.

Molecular weight

234.33 grams per mole, a measure of the mass of one mole of the compound.

Physical properties

Clear colorless liquid with a characteristic odor, describing the appearance and smell of the compound.

Safety precautions

Potential health hazards and flammability, emphasizing the need for proper handling and safety protocols.

Upstream product

• 1132-66-7 1-phenoxyhexane 
• 79-03-8 propionyl chloride 
• 123-62-6 propionic acid anhydride 
• 111-25-1 1-bromo-hexane 
• 70-70-2 4-hydroxypropiophenone 

Downstream Products

• 1162125-78-1 3-(dimethylamino)-1-(4-(hexyloxy)phenyl)-2-methylpropan-1-one 

Relevant articles and documents

Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors

We have previously reported the discovery and preliminary structure activity relationships of a series of β-aminoketones that disrupt the binding of coactivators to TR. However, the most active compounds had moderate inhibitory potency and relatively high cytotoxicity, resulting in narrow therapeutic index. Additionally, preliminary evaluation of in vivo toxicology revealed a significant dose related cardiotoxicity. Here we describe the improvement of pharmacological properties of thyroid hormone receptor coactivator binding inhibitors. A comprehensive survey of the effects of substitutents in key areas of the molecule was carried out based on mechanistic insight from the earlier report. This study revealed that both electron withdrawing and hydrophobic substituents on the aromatic ring led to higher potency. On the other hand, moving from an alkyl to a sulfonyl alkyl side chain led to reduced cytotoxicity. Finally, utilization of amine moieties having low pKa's resulted in lowered ion channel activity without any loss of pharmacological activity.

Catalytic Friedel-Crafts acylation of alkoxybenzenes mediated by aluminum hydrogensulfate in solution and solvent-free conditions

Friedel-Crafts acylation of alkoxybenzenes was achieved efficiently by a reaction with aliphatic acid anhydrides in the presence of catalytic amounts of aluminum hydrogensulfate, Al(HSO4)3, in nitromethane and under solvent-free conditions. Alkylbenzenes and aryl halides, as well as aromatic anhydrides, remained intact under these conditions.

On some 4-alkoxyphenyl alkyl ketones and their aminomethylation.

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