573675-39-5

Usage

Uses

Used in Medicinal Chemistry:
5-bromo-3-hydroxyisoindolin-1-one is used as a potential anti-cancer and anti-inflammatory agent due to its biological activities. Its unique structure allows it to modulate various signaling pathways and target specific cellular processes, offering therapeutic benefits in the treatment of cancer and inflammatory diseases.
Used in Organic Synthesis:
5-bromo-3-hydroxyisoindolin-1-one is used as a building block in the synthesis of pharmaceutical compounds. Its reactivity and selectivity in chemical transformations make it a valuable component in the development of new drugs and other bioactive molecules.
Used in Chemical Transformations:
5-bromo-3-hydroxyisoindolin-1-one is used as a versatile reagent in various chemical reactions, such as cross-coupling, substitution, and cyclization. Its unique bromo group allows for selective functionalization and the formation of new chemical bonds, contributing to the synthesis of complex organic molecules.
Used in Drug Development:
5-bromo-3-hydroxyisoindolin-1-one is used as a starting material in the development of new drugs. Its potential as an anti-cancer and anti-inflammatory agent, along with its versatility in chemical transformations, makes it a promising candidate for the design and synthesis of novel therapeutic agents.
Used in Research and Development:
5-bromo-3-hydroxyisoindolin-1-one is used as a research tool in the study of chemical reactivity, selectivity, and the development of new synthetic methods. Its unique properties and potential applications in medicinal chemistry and drug development make it an important compound for further investigation and exploration.

Upstream product

• 6941-75-9 5-Bromoisoindoline-1,3-dione 
• 573675-37-3 4-bromo-2-(dibromomethyl)benzonitrile 

Downstream Products

• 75884-70-7 6-bromophthalazin-1-ol 
• 1416977-97-3 (E)-2-(6-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1-oxophthalazin-2(1H)-yl)-N-(2,2,2-trifluoroethyl)acetamide 
• 1416980-17-0 (E)-2-(6-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1-oxophthalazin-2(1H)-yl)acetic acid 
• 1416980-16-9 (E)-Ethyl 2-(6-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1-oxophthalazin-2(1H)-yl)acetate 
• 868662-12-8 6-(4-trifluoromethylphenyl)-2H-phthalazin-1-one 
• 897661-91-5 6-(4-methoxy-2-methylphenyl)-2H-phthalazin-1-one 
• 897661-90-4 6-(4-chlorophenyl)-2H-phthalazin-1-one 
• 75884-70-7 6-bromophthalazin-1(2H)-one 

Relevant academic research and scientific papers

Pesticidal compositions and processes related thereto

This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.

PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO

This document discloses molecules having the following formula ("Formula One"): and processes associated therewith.

PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO

This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.

PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO

This document discloses molecules having the following formula ("Formula One") and processes associated therewith.

PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO

This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.

PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO

This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.

PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO

This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.

PHTHALAZINE DERIVATIVES

The present invention relates to novel phthalazine derivatives and, more particularly, to phthalazine derivatives that are useful as protein kinase inhibitors. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and methods of treatment using the compounds.

PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2/su

A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties

Melanin-concentrating hormone receptor antagonists containing thieno- and a benzopyridazinone cores were designed and tested as potential anorectic agents. These ligands showed high affinity for the receptor, potent functional activity in vitro, and good oral bioavailability in rats. The thiophene analogue exhibited low iv clearance, long half-life, and high brain penetration. In obese rats, the thienopyridazinone demonstrated a dose-dependent reduction in feeding and body weight with doses between 1 and 10 mg kg-1.