573701-88-9

Basic information

• Product Name: methyl 2-amino-2-(2-fluorophenyl)acetate
• Synonyms: methyl 2-amino-2-(2-fluorophenyl)acetate;Amino-(2-fluoro-phenyl)-acetic acid methyl ester
• CAS NO: 573701-88-9
• Molecular Formula: C₉H₁₀FNO₂
• Molecular Weight: 183.1796032
• Mol File: 573701-88-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: methyl 2-amino-2-(2-fluorophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-amino-2-(2-fluorophenyl)acetate(573701-88-9)
• EPA Substance Registry System: methyl 2-amino-2-(2-fluorophenyl)acetate(573701-88-9)

Safety Data

• Hazardous Substances Data: 573701-88-9(Hazardous Substances Data)

Usage

General Description

Methyl 2-amino-2-(2-fluorophenyl)acetate is a chemical compound with the formula C10H12FNO2. It is an amino acid derivative with a methyl ester group, an amino group, and a fluorophenyl group. methyl 2-amino-2-(2-fluorophenyl)acetate is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. It can also be used as a building block in the production of biologically active molecules and as a reagent in organic chemistry. Methyl 2-amino-2-(2-fluorophenyl)acetate has potential applications in the pharmaceutical industry and in academic research for the development of new drugs and therapeutic compounds.

Upstream product

• 67-56-1 methanol 
• 84145-28-8 (+/-)-2-amino-2'-fluorophenylacetic acid 
• 445-27-2 2'-Fluoroacetophenone 
• 132115-73-2 methyl 2-fluoro-α-oxo-benzeneacetate 
• 137684-19-6 o-fluorophenylglyoxal 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 84145-28-8 (+/-)-2-amino-2'-fluorophenylacetic acid 

Relevant articles and documents

Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.

Rh-catalyzed asymmetric hydrogenation of racemic aldimines via dynamic kinetic resolution

Catalyzed by a rhodium complex of P-stereogenic diphosphine ligand trichickenfootphos (TCFP), asymmetric hydrogenation of racemic aldimines via dynamic kinetic resolution has been realized for the preparation of chiral arylglycines with good yields and enantioselectivities.