132115-73-2

Upstream product

• 57486-67-6 methyl o-fluorophenylacetate 
• 79477-86-4 2-fluorophenylglyoxylic acid 
• 67-56-1 methanol 
• 137684-19-6 o-fluorophenylglyoxal 
• 445-27-2 2'-Fluoroacetophenone 
• 74-88-4 methyl iodide 
• 80277-41-4 2-fluorobenzoyl cyanide 
• 887027-36-3 methyl α-diazo-α-(2-fluorophenyl)acetate 

Downstream Products

• 326801-14-3 Methyl 2-fluorophenylglyoxylate O-tert-butyloxime 
• 455-68-5 methyl 3-fluorobenzoate 
• 266693-63-4 methyl [2-(3-Bromo-4-fluorophenoxy)phenyl]oxoacetate 
• 192947-78-7 methyl 2-[1-(4-chlorophenyl)-3-pyrazolyloxy]phenylglyoxalate 
• 1225870-67-6 C₉H₇FO₂ 
• 192884-55-2 methyl 2-(2-fluorophenyl)-2-hydroxyacetate 
• 573701-88-9 methyl (±)-2-amino-2-(2-fluorophenyl)acetate 

Relevant academic research and scientific papers

Sex hormone releasing hormone receptor antagonists and uses thereof

Gonadotropin-releasing hormone receptor antagonists and uses thereofThe invention relates to the field of organic chemistry, in particular to a compound or a pharmaceutically acceptable salt thereof. Isomer, prodrug, polymorph or solvate as well as prepar

Carbene-Catalyzed Enantioselective Aromatic N-Nucleophilic Addition of Heteroarenes to Ketones

The aromatic nitrogen atoms of heteroarylaldehydes are activated by carbene catalysts to react with ketone electrophiles. Multi-functionalized cyclic N,O-acetal products are afforded in good to excellent yields and optical purities. Our reaction involves the formation of an unprecedented aza-fulvene-type acylazolium intermediate. A broad range of N-heteroaromatic aldehydes and electron-deficient ketone substrates works effectively in this transformation. Several of the chiral N,O-acetal products afforded through this protocol exhibit excellent antibacterial activities against Ralstonia solanacearum (Rs) and are valuable in the development of novel agrichemicals for plant protection.

Method for preparing spiro beta-lactam

The invention discloses a method for preparing spiro beta-lactam. The method comprises the following step: carrying out [2+1] cyclization reaction on beta-lactam and keto ester under the condition ofa phosphine catalyst to generate spiro beta-lactam. The

Rh-catalyzed asymmetric hydrogenation of racemic aldimines via dynamic kinetic resolution

Catalyzed by a rhodium complex of P-stereogenic diphosphine ligand trichickenfootphos (TCFP), asymmetric hydrogenation of racemic aldimines via dynamic kinetic resolution has been realized for the preparation of chiral arylglycines with good yields and enantioselectivities.

Asymmetric Hydrogenation of α-Substituted Acrylic Acids Catalyzed by a Ruthenocenyl Phosphino-oxazoline-Ruthenium Complex

Asymmetric hydrogenation of various α-substituted acrylic acids was carried out using RuPHOX-Ru as a chiral catalyst under 5 bar H2, affording the corresponding chiral α-substituted propanic acids in up to 99% yield and 99.9% ee. The reaction could be performed on a gram-scale with a relatively low catalyst loading (up to 5000 S/C), and the resulting product (97%, 99.3% ee) can be used as a key intermediate to construct bioactive chiral molecules. The asymmetric protocol was successfully applied to an asymmetric synthesis of dihydroartemisinic acid, a key intermediate required for the industrial synthesis of the antimalarial drug artemisinin.

An efficient synthesis of aryl α-keto esters

A new one-pot approach for the synthesis of aryl α-keto ester based on the diazo transfer and oxidation of diazo group is developed.

Oxime amides and hydrazone amides having fungicidal activity

The invention relates to compounds having usefulness in the control of Take-All disease in plants, particularly cereals, a method for the control of Take-All disease, and fungicidal compositions for carrying out the method. Compounds of the invention are oximes or hydrazones of arylgloxamides or heteroarylglyoxamides or cycloalkenylglyoxamides.

Oxime amides and hydrazone amides having fungicidal activity

The invention relates to compounds having usefulness in the control of Take-All disease in plants, particularly cereals, a method for the control of Take-All disease, and fungicidal compositions for carrying out the method. Compounds of the invention are oximes or hydrazones of arylgloxamides or heteroarylglyoxamides or cycloalkenylglyoxamides.

Imino oxyphenyl acetic acid derivatives, methods and intermediates for their preparation and use thereof

2-Iminooxyphenylacetic acid derivatives STR1 where the substituents and the index have the following meanings: R1 is C(CO2 CH3)=NOCH3 (Ia), C(CONHCH3)=NOCH3 (Ib), C(CONH2)=NOCHs

6-Beta-(alpha-etherified oxymino)-acyl amino penicillins

Compounds of formula (I): wherein R1 is optionally substituted phenyl and R is a cycloalkyl group having an alkyl substituent in the 1-position; or R1 is phenyl substituted by at least one fluorine atom and/or at least one trifluoromethyl group and R is hydrogen or an organic radical, and their salts and esters, are useful in the treatment of bacterial infections in humans and animals.