57381-26-7Relevant articles and documents
Irsogladine maleate preparation method
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Paragraph 0009; 0010, (2019/05/16)
The invention belongs to the field of organic matter synthesis, and particularly relates to an irsogladine maleate preparation method, wherein p-dichlorobenzene is used as a starting raw material, andfive reactions of acetylation, bromoform reaction, cyanation, cyclization and salt formation are performed to prepare the target compound. According to the present invention, the new irsogladine maleate preparation method is used, can significantly accelerate the reaction rate and improve the yield, has advantages of cost reducing, environment protection, simple operation and convenient post-treatment, and is suitable for industrial production.
Repositioning irsogladine to Hsp90 inhibitor
Seo, Young Ho
supporting information, p. 1495 - 1499 (2015/07/15)
Heat shock protein 90 (Hsp90) is a ubiquitous adenosine triphosphate (ATP)-dependent molecular chaperone and represents an attractive cancer therapeutic target due to its role in maintaining the correct folding and stability of many oncogenic proteins. In