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57381-26-7

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57381-26-7 Usage

Biological Activity

irsogladine is a pde4 inhibitor and muscarinic acetylcholine receptor binder.irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (p < 0.02, p < 0.001), in tpa-deficient mic

Check Digit Verification of cas no

The CAS Registry Mumber 57381-26-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,3,8 and 1 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 57381-26:
(7*5)+(6*7)+(5*3)+(4*8)+(3*1)+(2*2)+(1*6)=137
137 % 10 = 7
So 57381-26-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H7Cl2N5/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7/h1-3H,(H4,12,13,14,15,16)

57381-26-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Irsogladine

1.2 Other means of identification

Product number -
Other names 2',5'-Dichlorobenzoguanamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57381-26-7 SDS

57381-26-7Relevant articles and documents

Irsogladine maleate preparation method

-

Paragraph 0009; 0010, (2019/05/16)

The invention belongs to the field of organic matter synthesis, and particularly relates to an irsogladine maleate preparation method, wherein p-dichlorobenzene is used as a starting raw material, andfive reactions of acetylation, bromoform reaction, cyanation, cyclization and salt formation are performed to prepare the target compound. According to the present invention, the new irsogladine maleate preparation method is used, can significantly accelerate the reaction rate and improve the yield, has advantages of cost reducing, environment protection, simple operation and convenient post-treatment, and is suitable for industrial production.

Repositioning irsogladine to Hsp90 inhibitor

Seo, Young Ho

supporting information, p. 1495 - 1499 (2015/07/15)

Heat shock protein 90 (Hsp90) is a ubiquitous adenosine triphosphate (ATP)-dependent molecular chaperone and represents an attractive cancer therapeutic target due to its role in maintaining the correct folding and stability of many oncogenic proteins. In

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