5744-59-2

Basic information

• Product Name: 1,5-DIMETHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID
• Synonyms: TIMTEC-BB SBB005424;1,5-DIMETHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID;1,5-DIMETHYLPYRAZOLE-3-CARBOXYLIC ACID;AKOS PAO-0685;BUTTPARK 37\06-98;1,5-Dimethyl-1H-pyrazole-3-carboxylic acid, 95+%;1,5-Dimethyl-1H-pyrazole-3-carboxylic acid ,97%;1,5-Dimethyl-1H-pyrazole-3-carboxylic acid ,99%
• CAS NO: 5744-59-2
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140.14
• Product Categories: Carboxylic Acids;Pyrazoles & Triazoles;Carboxylic Acids;Pyrazoles & Triazoles
• Mol File: 5744-59-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 170°C
• Boiling Point: 302.4 ºC at 760 mmHg
• Flash Point: 136.7 ºC
• Appearance: /Solid
• Density: 1.28 g/cm³
• Vapor Pressure: 0.000438mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 2-8°C
• PKA: 4.12±0.10(Predicted)
• CAS DataBase Reference: 1,5-DIMETHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-DIMETHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID(5744-59-2)
• EPA Substance Registry System: 1,5-DIMETHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID(5744-59-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 5744-59-2(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C6H8N2O2/c1-4-3-5(6(9)10)7-8(4)2/h3H,1-2H3,(H,9,10)

Upstream product

• 10250-61-0 1,5-dimethyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 5744-51-4 ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate 
• 4027-57-0 ethyl 5-methyl-1H-pyrazole-3-carboxylate 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 696-22-0 5-methyl-2H-pyrazole-3-carboxylic acid 
• 77-78-1 dimethyl sulfate 
• 60-34-4 methylhydrazine 

Downstream Products

• 1297536-62-9 1,5-dimethyl-1H-pyrazole-3-carboxylic acid {2-[5-(3,4-dichlorophenyl)furan-2-yl]ethyl}amide 
• 1197290-99-5 N-((1s,4s)-4-(1,5-dimethyl-1H-pyrazole-3-carboxamido)cyclohexyl)-5-fluoro-2-(3-iodophenoxy)nicotinamide 
• 1610737-11-5 N-((1s,4s)-4-(1,5-dimethyl-1H-pyrazole-3-carboxamido)cyclohexyl)-2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-3'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamide trifluoroacetic acid salt 
• 1628847-82-4 2-(2'-((1,4-oxazepan-4-yl)methyl)-4'-hydroxybiphenyl-3-yloxy)-N-((1s,4s)-4-(1,5-dimethyl-1H-pyrazole-3-carboxamido)cyclohexyl)-5-fluoronicotinamide trifluoroacetic acid salt 
• 1403333-47-0 (S)-N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1,5-dimethyl-1H-pyrazol-3-yl)-1,2,4-oxadiazole-3-carboxamide 
• 1313389-01-3 3-benzyl-8-(1,5-dimethyl-1H-pyrazol-3-yl)-1H-purine-2,6(3H,7H)-dione 

Relevant articles and documents

PYRAZOLE DERIVATIVES AS H4 ANTAGONIST COMPOUNDS

The disclosures herein relate to novel compounds of formula (1): and salts thereof, wherein A; X;n; R1 and R2 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with H4 receptors.

3-Isoxazoyl derivatives endowed with anticonvulsant activity, procedure for their preparation and their pharmaceutical compositions

The object of the invention is heterocyclic compounds of general formula (I) endowed with anticonvulsant activity: STR1 in which Y is selected from --O--, --S-- and STR2 R4 being H or optionally substituted alkyl, acyl or benzyl, Z is selected

Pyrazolodiazepines. 1,3 (and 2,3) dialkyl 4,6 dihydro 8 arylpyrazolo[4,3 e][1,4] diazepin 5 ones as antianxiety agents

A series of 1, 3 (and 2, 3) dialkyl 4, 6 dihydro 8 arylpyrazolo [4, 3 e][1, 4] diazepin 5 ones was synthesized and evaluated for psychotropic activity. Intermediates are new dialkylnitropyrazolyl aryl ketones prepared from dialkylnitropyrazolecarboxylic acids. Many of these pyrazolodiazepines exhibit high CNS activity in animals. One compound, 1 ethyl 4, 6 dihydro 3 methyl 8 phenylpyrazolo [4, 3 e] [1, 4] diazepin 5 (1H) one is about as potent as diazepam as an antianxiety agent with less sedative properties and is being studied in the clinic.