696-22-0

Basic information

• Product Name: 3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
• Synonyms: 3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID;3-methyl-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE);3-Methyl-5-pyrazolecarboxylic acid;1H-Pyrazole-3-carboxylic acid, 5-Methyl-;5(or 3)-Methyl-pyrazole-3(or 5)-carboxylic Acid;InChI=1/C5H6N2O2/c1-3-2-4(5(8)9)7-6-3/h2H,1H3,(H,6,7)(H,8,9;Pyrazole-3-carboxylic acid, 5-methyl-;Pyrazole-5-carboxylic acid, 3-methyl-
• CAS NO: 696-22-0
• Molecular Formula: C₅H₆N₂O₂
• Molecular Weight: 126.11
• EINECS: 206-953-0
• Mol File: 696-22-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 236-240℃
• Boiling Point: 388.8 °C at 760 mmHg
• Flash Point: 188.9 °C
• Appearance: /
• Density: 1.404 g/cm³
• Vapor Pressure: 9.69E-07mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID(696-22-0)
• EPA Substance Registry System: 3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID(696-22-0)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 696-22-0(Hazardous Substances Data)

Usage

General Description

3-Methyl-1H-pyrazole-5-carboxylic acid, also known as 3-Methylpyrazole-5-carboxylic acid, is a chemical compound with the molecular formula C6H6N2O2. It is a derivative of pyrazole and is classified as a carboxylic acid. 3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID is used as a building block in the synthesis of pharmaceuticals and other organic compounds. It has also been studied for its potential biological and pharmacological activities. As a carboxylic acid, 3-Methyl-1H-pyrazole-5-carboxylic acid is capable of forming salts and esters, and it can participate in various chemical reactions that are typical of carboxylic acids. Overall, this compound has diverse applications in the field of organic chemistry and may have potential medicinal uses as well.

InChI:InChI=1/C5H6N2O2/c1-3-2-4(5(8)9)7-6-3/h2H,1H3,(H,6,7)(H,8,9)

Upstream product

• 7647-01-0 hydrogenchloride 
• 49664-33-7 2,7-dimethyl-4H,9H-dipyrazolo<1,5-a,1',5'-d>pyrazine-4,9-dione 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 376387-68-7 1-(tert-butyl)-5-methyl-1H-pyrazole-3-carboxylic acid 
• 25016-17-5 3-methyl-1H-pyrazole-5-carboxylic acid methyl ester 
• 20577-61-1 methyl 2,4-dioxopentanoate 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 4027-57-0 ethyl 5-methyl-2H-pyrazole-3-carboxylate 
• 135351-18-7 1,1,1-trichloro-4-methoxy-3-penten-2-one 
• 686-92-0 1,1,1-trichloropentan-2,4-dione 
• 64-17-5 ethanol 
• 5699-58-1 2,4-dioxo-pentanoic acid 
• 56542-16-6 semicarbazide acetate 

Downstream Products

• 5744-56-9 1,3-dimethylpyrazol-5-carboxylic acid 
• 82231-52-5 4-bromo-5-methyl-1⁽²⁾H-pyrazole-3-carboxylic acid 
• 5744-59-2 1,5-dimethyl-1H-pyrazole-3-carboxylic acid 
• 5334-38-3 3-methyl-4-nitropyrazole-5-carboxylic acid 
• 68375-43-9 5-methyl-4-nitro-1⁽²⁾H-pyrazole-3-carboxylic acid methylamide 
• 68375-44-0 4-amino-5-methyl-1⁽²⁾H-pyrazole-3-carboxylic acid methylamide 
• 87375-38-0 5-acetyl-1,3-dimethylpyrazole 
• 1297537-00-8 N-(2-(3-(3,4-dichlorophenyl)-1H-pyrazol-1-yl)ethyl)-3-methyl-1H-pyrazole-5-carboxamide 
• 1297537-84-8 N-(2-(3-(3-methoxy-4-nitrophenyl)-1H-pyrazol-1-yl)ethyl)-5-methyl-1H-pyrazole-3-carboxamide 
• 1178881-58-7 3-Methyl-N-({1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-3-phenylpiperidin-3-yl}methyl)-1H-pyrazole-5-carboxamide 

Relevant articles and documents

Cleavage of Carboxylic Esters by Aluminum and Iodine

A one-pot procedure for deprotecting carboxylic esters under nonhydrolytic conditions is described. Typical alkyl carboxylates are readily deblocked to the carboxylic acids by the action of aluminum powder and iodine in anhydrous acetonitrile. Cleavage of lactones affords the corresponding ω-iodoalkylcarboxylic acids. Aryl acetylates undergo deacetylation with the participation of the neighboring group. This method enables the selective cleavage of alkyl carboxylic esters in the presence of aryl esters.

Regio-specific synthesis of new 1-(tert-butyl)-1H-pyrazolecarboxamide derivatives

Regio-specific and non-regiospecific condensation reactions on 1,3-dicarbonyl compounds rendered 1,3,5-trisubstituted pyrazoles. Herein, the control of regio-specificity was a significant improvement in pyrazole research. A high yield acylation of poorly

NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS

The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.