696-22-0

Usage

Uses

Used in Pharmaceutical Synthesis:
3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID is used as a building block for the synthesis of pharmaceuticals and other organic compounds. Its unique structure and reactivity make it a valuable component in the development of new drugs and therapeutic agents.
Used in Organic Chemistry Research:
In the field of organic chemistry, 3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID is used as a key intermediate in various chemical reactions. Its carboxylic acid functionality allows it to participate in esterification, amidation, and other condensation reactions, contributing to the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID has been studied for its potential biological and pharmacological activities. Its ability to form salts and esters, along with its reactivity in chemical reactions, makes it a promising candidate for the development of new medicinal compounds with therapeutic applications.
Overall, 3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID is a versatile chemical compound with applications in pharmaceutical synthesis, organic chemistry research, and medicinal chemistry, showcasing its potential in the development of new drugs and therapeutic agents.

InChI:InChI=1/C5H6N2O2/c1-3-2-4(5(8)9)7-6-3/h2H,1H3,(H,6,7)(H,8,9)

Upstream product

• 64-17-5 ethanol 
• 5699-58-1 2,4-dioxo-pentanoic acid 
• 56542-16-6 semicarbazide acetate 
• 7647-01-0 hydrogenchloride 
• 49664-33-7 2,7-dimethyl-4H,9H-dipyrazolo<1,5-a,1',5'-d>pyrazine-4,9-dione 
• 686-92-0 1,1,1-trichloropentan-2,4-dione 
• 135351-18-7 1,1,1-trichloro-4-methoxy-3-penten-2-one 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 4027-57-0 ethyl 5-methyl-2H-pyrazole-3-carboxylate 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 20577-61-1 methyl 2,4-dioxopentanoate 
• 25016-17-5 3-methyl-1H-pyrazole-5-carboxylic acid methyl ester 
• 376387-68-7 1-(tert-butyl)-5-methyl-1H-pyrazole-3-carboxylic acid 

Downstream Products

• 120800-48-8 1-acetyl-5-methyl-1H-pyrazole-3-carboxylic acid 
• 5744-56-9 1,3-dimethylpyrazol-5-carboxylic acid 
• 82231-52-5 4-bromo-5-methyl-1⁽²⁾H-pyrazole-3-carboxylic acid 
• 89270-37-1 5-methyl-2H-pyrazole-3-carboxylic acid N-methylhydrazide 
• 868139-67-7 benzyl 2-(3-methyl-1H-pyrazole-5-carbonyl)piperazine-1-carboxylate 
• 89270-70-2 5-Methyl-1H-pyrazole-3-carboxylic acid N-methyl-N'-[1-phenyl-meth-(E)-ylidene]-hydrazide 
• 1297537-84-8 N-(2-(3-(3-methoxy-4-nitrophenyl)-1H-pyrazol-1-yl)ethyl)-5-methyl-1H-pyrazole-3-carboxamide 
• 1297537-00-8 N-(2-(3-(3,4-dichlorophenyl)-1H-pyrazol-1-yl)ethyl)-3-methyl-1H-pyrazole-5-carboxamide 
• 5334-38-3 3-methyl-4-nitropyrazole-5-carboxylic acid 
• 68375-43-9 5-methyl-4-nitro-1⁽²⁾H-pyrazole-3-carboxylic acid methylamide 
• 68375-44-0 4-amino-5-methyl-1⁽²⁾H-pyrazole-3-carboxylic acid methylamide 
• 17827-60-0 methyl 1-methyl-1H-pyrazole-5-carboxylate 

Relevant academic research and scientific papers

Cleavage of Carboxylic Esters by Aluminum and Iodine

A one-pot procedure for deprotecting carboxylic esters under nonhydrolytic conditions is described. Typical alkyl carboxylates are readily deblocked to the carboxylic acids by the action of aluminum powder and iodine in anhydrous acetonitrile. Cleavage of lactones affords the corresponding ω-iodoalkylcarboxylic acids. Aryl acetylates undergo deacetylation with the participation of the neighboring group. This method enables the selective cleavage of alkyl carboxylic esters in the presence of aryl esters.

C-3 NOVEL TRITERPENONE WITH C-17 REVERSE AMIDE DERIVATIVES AS HIV INHIBITORS

The present invention relates to C-3 novel triterpenone with C-17 reverse amide compounds of Formula (I); and pharmaceutically acceptable salts thereof, wherein ring Formula (II), R1, R2, R3, R4, R5, R6, R7, 'n' and 'm' are as defined in Formula (I). The invention also relates to C-3 novel triterpenone with C-17 reverse amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.

Regio-specific synthesis of new 1-(tert-butyl)-1H-pyrazolecarboxamide derivatives

Regio-specific and non-regiospecific condensation reactions on 1,3-dicarbonyl compounds rendered 1,3,5-trisubstituted pyrazoles. Herein, the control of regio-specificity was a significant improvement in pyrazole research. A high yield acylation of poorly

With anti-tumor activity of the 3-substituted pyrazole-5-amide compound and use thereof (by machine translation)

The invention belongs to the field of medical technology, relates to a sulfenyl class with anti-tumor activity of the compounds, in particular to a thio-containing the 3-substituted pyrazole-5-amide compounds, and its pharmaceutically acceptable salt, hydrate, and the compound is a pharmaceutical composition of the active ingredient, the preparation and and its histone deacetylase inhibitor for the treatment and/or use in the prevention of cancer. The compounds of general formula I to shows, and its pharmaceutically acceptable salt, hydrate structure is as follows :? wherein R 1, R 2 such as the claim and the specification. (by machine translation)

NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS

The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.

Synthesis and anti-TMV activity of novel N-(3-alkyl-1H-pyrazol-4-yl)-3- alkyl-4-substituted-1H-pyrazole-5-carboxamides

In order to investigate the biological activity of novel bis-pyrazole compounds, a series of N-(3-alkyl-5-(N-methylcarbamyl)-1H-pyrazol-4-yl)-3-alkyl- 4-substituted-1H-pyrazole-5-carboxamides were designed and synthesized with ethyl 3-alkyl-1H-pyrazole-5-

Metathesis reactions of pyrazolotriazinones generate dynamic combinatorial libraries

(Chemical Equation Presented) Reversible metathesis reactions of pyrazolotriazinones and aliphatic aldehydes or ketones proceed in aqueous, phosphate-buffered media at pH 4 and 40-60°C to generate thermodynamically controlled mixtures of heterocycles.

Synthesis of hydroxypyrazoles and 1-methyl-3-isoxazolones via haloform reactions

The synthesis of a new series of hydroxypyrazoles (2a-f) and 2-methyl-3-isoxazolones (3a-d) from the cyclocondensation reaction of trichloromethyl-substituted 1,3-dielectrophiles (1a-f) with dry hydrazine and N-methylhydroxylamine is reported. The regiospecific cyclocondensation took place with the elimination of the trichloromethyl group in a haloform type reaction when acetonitrile under basic medium was used. The structure of compounds 2 and 3 were determined mainly by 1H and 13C NMR spectroscopy.

Synthesis for 7-alkylamino-3-methylpyrazolo [4,3-d]pyrimidines

An improved synthesis is disclosed for 7-alkylamino-3-methylpyrazolo[4,3-d]pyrimidines, which are known to be potent cytokinin antagonists.