57478-19-0

Basic information

• Product Name: 4-(4-TRIFLUOROMETHYLPHENOXY)ANILINE
• Synonyms: 4-(4-TRIFLUOROMETHYLPHENOXY)ANILINE;P-(4-TRIFLUOROMETHYLPHENOXY)-ANILINE;4-(4-Ttifluoromethylphenoxy)aniline;Benzenamine, 4-[4-(trifluoromethyl)phenoxy]-;[4-[(4-Trifluoromethylphenyl)oxy]phenyl]amine;4-[(4-Trifluoromethylphenyl)oxy]aniline
• CAS NO: 57478-19-0
• Molecular Formula: C₁₃H₁₀F₃NO
• Molecular Weight: 253.22
• Mol File: 57478-19-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 70-80℃
• Boiling Point: 326℃
• Flash Point: 151℃
• Appearance: /
• Density: 1.293
• Vapor Pressure: 0.000226mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.41±0.10(Predicted)
• CAS DataBase Reference: 4-(4-TRIFLUOROMETHYLPHENOXY)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-TRIFLUOROMETHYLPHENOXY)ANILINE(57478-19-0)
• EPA Substance Registry System: 4-(4-TRIFLUOROMETHYLPHENOXY)ANILINE(57478-19-0)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 57478-19-0(Hazardous Substances Data)

Usage

General Description

4-(4-trifluoromethylphenoxy)aniline is a chemical compound with the molecular formula C13H10F3NO. It is a white solid at room temperature and is primarily used as an intermediate in the production of pharmaceuticals, agrochemicals, and dyes. 4-(4-TRIFLUOROMETHYLPHENOXY)ANILINE is a substituted aniline, with a trifluoromethyl group attached to the phenyl ring and a phenoxy group attached to the amino group. It is important to handle this chemical with caution as it may cause skin and eye irritation, and it should be stored in a cool, dry, and well-ventilated area.

InChI:InChI=1/C13H10F3NO/c14-13(15,16)9-1-5-11(6-2-9)18-12-7-3-10(17)4-8-12/h1-8H,17H2

Upstream product

• 34859-78-4 1-nitro-4-(4-(trifluoromethyl)phenoxy)benzene 
• 402-44-8 4-Fluorobenzotrifluoride 
• 123-30-8 4-amino-phenol 
• 100-00-5 4-chlorobenzonitrile 
• 402-45-9 4-hydroxybenzotrifluoride 
• 350-46-9 4-Fluoronitrobenzene 
• 98-56-6 4-chlorobenzotrifluoride 
• 402-43-7 p-trifluoromethylphenyl bromide 

Downstream Products

• 1008530-98-0 N-[4-(4-trifluoromethylphenoxy)phenyl]methanesulfonamide 
• 321597-60-8 N-(4-CYCLOHEXYLPHENYL)-3-HYDROXYPYRIDINE-2-CARBOXAMIDE 
• 481687-38-1 5-nitro-N-para-[4-(trifluoromethyl)phenoxy] phenyl-isothiazole-3-carboxamide 
• 189875-68-1 C₁₇H₁₂F₃NO₄ 
• 1366234-49-2 C₁₇H₁₃F₃N₄O 
• 1300031-15-5 2,7-dimethyl-N-(4-(4-(trifluoromethyl)phenoxy)phenyl)imidazo[1,2-a]pyridine-3-carboxamide 

Relevant articles and documents

AGRICULTURAL CHEMICALS

The present invention relates to picolinic acid derivatives that are useful in treating fungal diseases ofplants.

Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response

Heme-regulated inhibitor (HRI), an eukaryotic translation initiation factor 2 alpha (eIF2α) kinase, plays critical roles in cell proliferation, differentiation, adaptation to stress, and hemoglobin disorders. HRI phosphorylates eIF2α, which couples cellular signals, including endoplasmic reticulum (ER) stress, to translation. We previously identified 1,3-diarylureas and 1-((1,4-trans)-4-aryloxycyclohexyl)-3-arylureas (cHAUs) as specific activators of HRI that trigger the eIF2α phosphorylation arm of ER stress response as molecular probes for studying HRI biology and its potential as a druggable target. To develop drug-like cHAUs needed for in vivo studies, we undertook bioassay-guided structure-activity relationship studies and tested them in the surrogate eIF2α phosphorylation and cell proliferation assays. We further evaluated some of these cHAUs in endogenous eIF2α phosphorylation and in the expression of the transcription factor C/EBP homologous protein (CHOP) and its mRNA, demonstrating significantly improved solubility and/or potencies. These cHAUs are excellent candidates for lead optimization for development of investigational new drugs that potently and specifically activate HRI.

Synthesis and biological evaluation of pentanedioic acid derivatives as farnesyltransferase inhibitors

Structure-based virtual screening of a commercial library identified pentanedioic acid derivatives (6 and 13b) as a kind of novel scaffold farnesyltransferase inhibitors (FTIs). Chemical modifications of the lead compounds, biological assays and analysis of the structure-activity relationships (SAR) were conducted to discover more potent FTIs. Some of them displayed excellent inhibition against FTase, and among them, the most active compound 13n with an IC50 value of 0.0029 μM and SAR analysis might be helpful to the discovery of more potent FTIs. This journal is