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4-(4-TRIFLUOROMETHYLPHENOXY)ANILINE, a chemical compound with the molecular formula C13H10F3NO, is a white solid at room temperature. It is a substituted aniline characterized by a trifluoromethyl group attached to the phenyl ring and a phenoxy group attached to the amino group. Due to its potential to cause skin and eye irritation, it requires careful handling and should be stored in a cool, dry, and well-ventilated area.

57478-19-0

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57478-19-0 Usage

Uses

Used in Pharmaceutical Industry:
4-(4-TRIFLUOROMETHYLPHENOXY)ANILINE is used as an intermediate in the production of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs, enhancing their therapeutic properties and effectiveness.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(4-TRIFLUOROMETHYLPHENOXY)ANILINE is utilized as an intermediate in the synthesis of agrochemicals, contributing to the development of more effective pesticides and other agricultural chemicals.
Used in Dye Industry:
4-(4-TRIFLUOROMETHYLPHENOXY)ANILINE is employed as an intermediate in the production of dyes, where its unique chemical structure allows for the creation of dyes with specific color properties and stability.

Check Digit Verification of cas no

The CAS Registry Mumber 57478-19-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,4,7 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 57478-19:
(7*5)+(6*7)+(5*4)+(4*7)+(3*8)+(2*1)+(1*9)=160
160 % 10 = 0
So 57478-19-0 is a valid CAS Registry Number.
InChI:InChI=1/C13H10F3NO/c14-13(15,16)9-1-5-11(6-2-9)18-12-7-3-10(17)4-8-12/h1-8H,17H2

57478-19-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(4-(Trifluoromethyl)phenoxy)aniline

1.2 Other means of identification

Product number -
Other names 4-[4-(trifluoromethyl)phenoxy]aniline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57478-19-0 SDS

57478-19-0Relevant articles and documents

AGRICULTURAL CHEMICALS

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Page/Page column 59; 61; 108, (2019/08/08)

The present invention relates to picolinic acid derivatives that are useful in treating fungal diseases ofplants.

Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels

Sairaman, Anjali,Cardoso, Fernanda Caldas,Bispat, Anjie,Lewis, Richard J.,Duggan, Peter J.,Tuck, Kellie L.

, p. 3046 - 3059 (2018/04/06)

Both N- and T-type calcium ion channels have been implicated in pain transmission and the N-type channel is a well-validated target for the treatment of neuropathic pain. An SAR investigation of a series of substituted aminobenzothiazoles identified a subset of five compounds with comparable activity to the positive control Z160 in a FLIPR-based intracellular calcium response assay measuring potency at both CaV2.2 and CaV3.2 channels. These compounds may form the basis for the development of drug leads and tool compounds for assessing in vivo effects of variable modulation of CaV2.2 and CaV3.2 channels.

Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response

Yefidoff-Freedman, Revital,Fan, Jing,Yan, Lu,Zhang, Qingwen,Dos Santos, Guillermo Rodrigo Reis,Rana, Sandeep,Contreras, Jacob I.,Sahoo, Rupam,Wan, Debin,Young, Jun,Dias Teixeira, Karina Luiza,Morisseau, Christophe,Halperin, Jose,Hammock, Bruce,Natarajan, Amarnath,Wang, Peimin,Chorev, Michael,Aktas, Bertal H.

, p. 5392 - 5406 (2017/07/22)

Heme-regulated inhibitor (HRI), an eukaryotic translation initiation factor 2 alpha (eIF2α) kinase, plays critical roles in cell proliferation, differentiation, adaptation to stress, and hemoglobin disorders. HRI phosphorylates eIF2α, which couples cellular signals, including endoplasmic reticulum (ER) stress, to translation. We previously identified 1,3-diarylureas and 1-((1,4-trans)-4-aryloxycyclohexyl)-3-arylureas (cHAUs) as specific activators of HRI that trigger the eIF2α phosphorylation arm of ER stress response as molecular probes for studying HRI biology and its potential as a druggable target. To develop drug-like cHAUs needed for in vivo studies, we undertook bioassay-guided structure-activity relationship studies and tested them in the surrogate eIF2α phosphorylation and cell proliferation assays. We further evaluated some of these cHAUs in endogenous eIF2α phosphorylation and in the expression of the transcription factor C/EBP homologous protein (CHOP) and its mRNA, demonstrating significantly improved solubility and/or potencies. These cHAUs are excellent candidates for lead optimization for development of investigational new drugs that potently and specifically activate HRI.

Synthesis and gas transport properties of novel functional polyimide/ZnO nanocomposite thin film membranes

Ahmadizadegan, Hashem

, p. 106778 - 106789 (2016/11/23)

In this study, the synthesis, morphology, thermal properties and gas transport of new polyimide/ZnO nanohybrid films were investigated. The novel diamine, containing functional trifluoromethyl groups, was prepared in two steps by the nucleophilic substitu

Synthesis and biological evaluation of pentanedioic acid derivatives as farnesyltransferase inhibitors

Yang, Liuqing,Liu, Wei,Mei, Hanbing,Zhang, Yuan,Yu, Xiaojuan,Xu, Yufang,Li, Honglin,Huang, Jin,Zhao, Zhenjiang

, p. 671 - 676 (2015/04/27)

Structure-based virtual screening of a commercial library identified pentanedioic acid derivatives (6 and 13b) as a kind of novel scaffold farnesyltransferase inhibitors (FTIs). Chemical modifications of the lead compounds, biological assays and analysis of the structure-activity relationships (SAR) were conducted to discover more potent FTIs. Some of them displayed excellent inhibition against FTase, and among them, the most active compound 13n with an IC50 value of 0.0029 μM and SAR analysis might be helpful to the discovery of more potent FTIs. This journal is

Quinolin-4(1 H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria

Rodrigues, Tiago,Da Cruz, Filipa P.,Lafuente-Monasterio, Maria J.,Gon?alves, Daniel,Ressurrei??o, Ana S.,Sitoe, Ana R.,Bronze, Maria R.,Gut, Jiri,Schneider, Gisbert,Mota, Maria M.,Rosenthal, Philip J.,Prude?ncio, Miguel,Gamo, Francisco-Javier,Lopes, Francisca,Moreira, Rui

supporting information, p. 4811 - 4815 (2013/07/19)

We present a novel series of quinolin-4(1H)-imines as dual-stage antiplasmodials, several-fold more active than primaquine in vitro against Plasmodium berghei liver stage. Among those, compounds 5g and 5k presented low nanomolar IC50 values. The compounds are metabolically stable and modulate several drug targets. These results emphasize the value of quinolin-4(1H)-imines as a new chemotype and their suitable properties for further drug development.

Synthesis characterizations and properties of a new fluoro-maleimide polymer

Mokhtar,Abd-Elaziz,Gomaa

experimental part, p. 616 - 620 (2010/06/13)

Novel 4-(4-trifluoromethyl)phenoxy N-phenyl-maleimide (FPMI) was synthesized. The free radical-initiated polymerization of FPMI was carried out in 1,4-dioxane solution using azobisisobutyronitrile as initiator. The monomer was investigated by FTIR, 1H NMR, 13C NMR and elemental analysis, while the polymer was investigated by FTIR, 1H NMR and 13C NMR. The effect of the monomer concentration, initiator concentration and temperature on the rate of polymerization (Rp) was studied. The activation energy of the polymerization was calculated (ΔE = 48.94 kJ/mol). The molecular weight of PFPMI (over(M, -)w and over(M, -)n) and polydispersity index of the polymer were determined by gel permeation chromatography and were equal to 73,500, 16,700 and 2.27, respectively. The properties of PFPMI, including thermal behavior, thermal stability, the glass transition temperature (Tg = 236 °C), photo-stability, solubility and solution viscosity were studied.

COMPOUNDS AND METHODS FOR PKC THETA INHIBITION

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Page/Page column 20 - 21; sheet 1, (2010/04/25)

The present invention provides a method of selectively inhibiting PKC in the presence of PKC, by administering to a subject in need thereof, a therapeutically effective amount of a compound of Formula I. The present invention also provides a method of inhibiting cytokine synthesis in a T cell, a method of inhibiting T cell proliferation, and a method of inhibiting the replication of and cytokine production by T lymphocytes, while not stimulating or inhibiting the replication of B lymphocytes.

Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors

Khim, Seock-Kyu,Bauman, John,Evans, Jarred,Freeman, Beverly,King, Beverly,Kirkland, Thomas,Kochanny, Monica,Lentz, Dao,Liang, Amy,Mendoza, Lisa,Phillips, Gary,Tseng, Jih-Lie,Wei, Robert G.,Ye, Hong,Yu, Limei,Parkinson, John,Guilford, William J.

scheme or table, p. 3895 - 3898 (2009/04/07)

The synthesis and biological evaluation of a series of aryl diamines as inhibitors of LTA4-h inhibitors are described. The optimization which led to the identification of the optimal para-substitution on the diphenyl ether moiety and diamine spacer is discussed. The resulting compounds such as 3l have excellent enzyme and cellular potency as well as desirable pharmacokinetic properties.

Trisubstituted heterocyclic compounds and their use as fungicides

-

, (2008/06/13)

Compounds of general formula (I): in which:Het represents a five or six membered saturated, partially unsaturated or aromatic ring containing between one and six heteroatoms of the group N, O, S, in which the heterocycle is substituted in an adjacent manner with -P-Q1-T-Q2, -GZ and Y, such that the substituant -GZ is adjacent to both. the other substituants being as defined in the description,process for preparing these compounds,fungicidal compositions comprising these compounds,processes for treating plants by applying these compounds or compositions.

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