57489-93-7

Usage

Uses

Used in Organic Synthesis:
5-PHENYL-FURAN-2-CARBONYL CHLORIDE is utilized as a reagent for introducing the carbonyl chloride functional group into a variety of organic compounds. Its ability to form this group is crucial for the synthesis of complex organic molecules and contributes to the advancement of chemical research and development.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 5-PHENYL-FURAN-2-CARBONYL CHLORIDE serves as a key intermediate in the synthesis of potential drug candidates. Its unique structure allows for the creation of new molecules with therapeutic properties, contributing to the discovery of novel treatments for various diseases.
Used in Agrochemical Development:
Similarly, in agrochemicals, 5-PHENYL-FURAN-2-CARBONYL CHLORIDE is employed as a precursor in the synthesis of compounds with pesticidal or herbicidal properties. Its reactivity and structural features are leveraged to develop new agrochemicals that can improve crop protection and yield.

InChI:InChI=1/C11H7ClO2/c12-11(13)10-7-6-9(14-10)8-4-2-1-3-5-8/h1-7H

Upstream product

• 52938-97-3 5-phenylfuran-2-carboxylic acid 
• 79-37-8 oxalyl dichloride 
• 585-70-6 5-bromo-furan-2-carboxylic acid 
• 52939-03-4 5-phenylfuran-2-carboxylic acid methyl ester 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 98-80-6 phenylboronic acid 
• 62-53-3 aniline 
• 88-14-2 2-furanoic acid 

Downstream Products

• 92973-00-7 {[1-Chloro-1-(5-phenyl-furan-2-yl)-meth-(Z)-ylidene]-amino}-acetic acid ethyl ester 
• 93770-60-6 [5-(5-Phenyl-furan-2-yl)-tetrazol-1-yl]-acetic acid 
• 92973-11-0 ethyl 5-(5-phenyl-2-furyl)-1-tetrazolyl acetate 
• 1044873-02-0 N-(5-phenyl-2-furoyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 
• 1044873-03-1 N-(5-phenyl-2-furoyl)-5,8-dichloro-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 
• 1013943-09-3 dimethyl 5-phenylfuran-2-carbonylphosphonate 
• 925705-62-0 3-{6-[(5-phenyl-furan-2-carbonyl)-amino]-pyridin-2-yl}-acrylic acid methyl ester 
• 1354698-21-7 N-5-phenyl-2-furoyl-1H-pyrazole 
• 1354698-32-0 N-5-phenyl-2-furoyl-1H-1,2,4-triazole 

Relevant academic research and scientific papers

Discovery of a series of 5-phenyl-2-furan derivatives containing 1,3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors

Gut microbial β-glucuronidases have drawn much attention due to their role as a potential therapeutic target to alleviate some drugs or their metabolites-induced gastrointestinal toxicity. In this study, fifteen 5-phenyl-2-furan derivatives containing 1,3

Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation

The α7 nicotinic acetylcholine receptor (nAChR) silent agonists, able to induce receptor desensitization and promote the α7 metabotropic function, are emerging as new promising therapeutic anti-inflammatory agents. Herein, we report the structure–activity

Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli β-glucuronidase inhibitors and their structure–inhibitory activity relationships

Gut microbial β-glucuronidases have the ability to deconjugate glucuronides of some drugs, thus have been considered as an important drug target to alleviate the drug metabolites-induced gastrointestinal toxicity. In this study, thiazolidin-2-cyanamide de

Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors

In this present study, a series of 5-phenyl-2-furan and 4-phenyl-2-oxazole derivatives were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. In vitro results showed that the synthesized compounds exhibited considerable inhibitory ac

Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists

The synthesis and biological evaluation as potential urotensin-II receptor antagonists of a series of 5-arylfuran-2-carboxamide derivatives 1, bearing a 4-(3-chloro-4-(piperidin-4-yloxy)benzyl)piperazin-1-yl group, are described. The results of a systemat

Novel S-Thiazol-2-yl-furan-2-carbothioate Derivatives as Potential T3SS Inhibitors against Xanthomonas oryzae on Rice

Bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv oryzae (Xoo) is considered as the most destructive disease of rice. The use of bactericides is among the most widely used traditional methods to control this destructive disease. The excessive an

Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell

Multidrug resistance (MDR) is a tendency in which cells become resistant to structurally and mechanistically unrelated drugs, which is mediated by P-glycoprotein (P-gp). It is one of the noteworthy problems in cancer therapy. As one of the most important

Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors

A series of 3,5-dimethylpyrazole derivatives containing 5-phenyl-2-furan moiety were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. Bioassay results showed that the title compounds exhibited considerable inhibitory activity agains

Tetrahydroquinoline and tetrahydroisoquinoline derivatives as potential selective PDE4B inhibitors

Tetrahydroquinoline and tetrahydroisoquinoline derivatives containing 2-phenyl-5-furan moiety were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. The bioassay results showed that title compounds showed good inhibitory activity aga

Synthesis and bioactivity of pyrazole and triazole derivatives as potential PDE4 inhibitors

A series of pyrazole and triazole derivatives containing 5-phenyl-2-furan functionality were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. The bioassay results showed that title compounds exhibited considerable inhibitory activit