57498-25-6

Basic information

• Product Name: 1-ETHYL-4-PHENYLPIPERAZINE
• Synonyms: 1-ETHYL-4-PHENYLPIPERAZINE
• CAS NO: 57498-25-6
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28
• Mol File: 57498-25-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 285.9°Cat760mmHg
• Flash Point: 118.9°C
• Appearance: /
• Density: 0.999g/cm³
• Vapor Pressure: 0.00272mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: 1-ETHYL-4-PHENYLPIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHYL-4-PHENYLPIPERAZINE(57498-25-6)
• EPA Substance Registry System: 1-ETHYL-4-PHENYLPIPERAZINE(57498-25-6)

Safety Data

• Hazardous Substances Data: 57498-25-6(Hazardous Substances Data)

Usage

General Description

1-ETHYL-4-PHENYLPIPERAZINE, also known as EPP, is a chemical compound with the molecular formula C14H20N2. It belongs to the class of piperazine derivatives and is commonly used as an intermediate in the synthesis of pharmaceuticals, particularly antipsychotic drugs. EPP has been studied for its potential therapeutic effects on various neurological and psychiatric disorders, including schizophrenia and depression. It is known to act as a potent dopamine receptor agonist, and its unique chemical structure makes it a promising candidate for drug development. EPP is also used in research and as a reference standard for analytical purposes. However, it is important to handle this compound with caution due to its potential health hazards and toxicity.

InChI:InChI=1/C12H18N2/c1-2-13-8-10-14(11-9-13)12-6-4-3-5-7-12/h3-7H,2,8-11H2,1H3

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 64-17-5 ethanol 
• 5308-25-8 4-ethylpiperazine 
• 108-90-7 chlorobenzene 
• 591-50-4 iodobenzene 
• 17763-67-6 Phenyl triflate 
• 62-53-3 aniline 
• 139-87-7 ethyldiethanolamine 
• 4004-95-9 1-phenylpiperazine hydrochloride 
• 75-07-0 acetaldehyde 
• 74-96-4 ethyl bromide 

Downstream Products

• 656257-43-1 1-(4-bromophenyl)-4-ethylpiperazine 
• 104393-82-0 C₁₂H₁₇⁽¹²⁵⁾IN₂ 

Relevant articles and documents

Mild N-Alkylation of Amines with Alcohols Catalyzed by the Acetate Ru(OAc)2(CO)(DiPPF) Complex

The acetate complex Ru(OAc)2(DiPPF) (2) obtained from Ru(OAc)2(PPh3)2 (1) and 1,1′-bis(diisopropylphosphino)ferrocene (DiPPF) reacts cleanly with formaldehyde affording Ru(OAc)2(CO)(DiPPF) (3) in high yield. The monocarbonyl complex 3 (0.4-2 mol %) efficiently catalyzes the N-alkylation of primary and secondary alkyl and aromatic amines using primary alcohols ROH (R=Et, nPr, nBu, PhCH2) under mild reaction conditions (30–100 °C) with an alcohol/amine molar ratio of 10-100. Formation of the monohydride RuH(OAc)(CO)(DiPPF) (4) has been observed by reaction of 3 with iPrOH in the presence of NEt3 at RT through an equilibrium reaction.

Amination with Pd-NHC complexes: Rate and computational studies on the effects of the oxidative addition partner

Pd-PEPPSI-IPent, a recently-developed N-heterocyclic carbene (NHC) complex, has been evaluated in amination reactions with secondary amines and it has shown superb reactivity under the most mildly basic reaction conditions. Rate and computational studies were conducted to provide insight into the mechanism of the transformation. The IPent catalyst coordinates to the amine much more strongly than the IPr variant, thus favouring deprotonation with comparatively weak bases. Indeed the reaction is first order in base and only slightly more than zeroth order in amine.

Mild and efficient copper-catalyzed N-arylation of alkylamines and N-H heterocycles using an oxime-phosphine oxide ligand

A mild and efficient copper-catalyzed system for N-arylation of alkylamines and N-H heterocycles with aryl iodides using a novel, readily prepared and highly stable oxime-functionalized phosphine oxide ligand was developed. The coupling reactions could even be performed in solvent-free conditions with moderate to good yields.