57500-53-5

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 

Downstream Products

• 56921-01-8 5-methyl-4-nitro-thiophene-2-carboxylic acid methyl ester 
• 946884-84-0 5-(4-isopropoxyphenoxy)thiophene-2-carbaldehyde 
• 42137-24-6 4-nitrothiophene-2-carbonitrile 
• 134890-74-7 C₂₀H₂₁N₃O₅S₂ 
• 134890-88-3 C₁₈H₁₇N₃O₅S₂ 
• 134890-69-0 2-{[Ethyl-(5-{[(E)-4-methoxy-phenylimino]-methyl}-thiophen-3-yl)-amino]-methylene}-malonic acid diethyl ester 
• 134890-71-4 4-Ethyl-2-{[(E)-4-methoxy-phenylimino]-methyl}-7-oxo-4,7-dihydro-thieno[3,2-b]pyridine-6-carboxylic acid ethyl ester 
• 134890-66-7 2-[(5-{[(E)-4-Methoxy-phenylimino]-methyl}-thiophen-3-ylamino)-methylene]-malonic acid diethyl ester 
• 134890-91-8 4-Ethyl-2-{[(E)-4-methoxy-phenylimino]-methyl}-7-oxo-4,7-dihydro-thieno[3,2-b]pyridine-6-carboxylic acid 
• 92159-29-0 4-(4-nitro-thiophen-2-ylmethylene)-2-phenyl-4H-oxazol-5-one 
• 13138-70-0 4-nitro-2-thiophenecarboxylic acid 
• 91182-62-6 4-nitro-thiophene-2-carbaldehyde-(4-bromo-phenylhydrazone) 
• 93282-96-3 4-nitro-thiophene-2-carbaldehyde phenylhydrazone 

Relevant academic research and scientific papers

Synthesis, protolytic equilibria, and antimicrobial action of nifuroxazide analogs

The present paper reports on the synthesis of four hydrazones derived from 5-nitro-2-furfural, 5-nitro-2-thiophenal, isoniazid, 2,4- and 3,4-dihydroxy-N′-methylenebenzohydrazide. The acid-base dissociation constants of these compounds were determined in an aqueous solution. The protolytic equilibria-related ability of hydrazones to “sense” anions in dimethyl sulfoxide-containing water of different concentrations is studied using spectrophotometry, NMR spectroscopy, and quantum chemistry methods. The antimicrobial action of the hydrazones was tested and compared with that of the known drug nifuroxazide.

Cyrhetrenylaniline and new organometallic phenylimines derived from 4- and 5-nitrothiophene: Synthesis, characterization, X-Ray structures, electrochemistry and in vitro anti-T. brucei activity

A novel series of cyrhetrenyl (3a-4a) and ferrocenyl (3b-4b) Schiff bases were synthesized through a condensation reaction, between the known 4-ferrocenylaniline (2b) or the unreported 4-cyhretrenylaniline (2a) with 4- or 5-nitrothiophenecarboxaldehyde. The structure of 2a and the new Schiff bases have been elucidated using conventional spectroscopic techniques (FT-IR, 1H and 13C NMR), mass spectrometry, and single-crystal X-ray diffraction analysis of compounds 2a, 4a and 3b. Cyclic voltammetry of organometallic phenylimines derived from 5-nitrothiophene showed NO2 group reduction potentials (E1/2 ≈ ?0.575 V) that were more anodic than those registered for their 4-nitro analogues (E1/2 ≈ ?0.981 V). All organometallic imines were tested against the bloodstream form of Trypanosoma brucei. Evaluation indicated that the most active complexes are the 5-nitrothiophene derivatives, 4a, which were remarkably more active than nifurtimox. In addition, complex 4b resulted in less toxicity to host L6 cells than nifurtimox. The results revealed that the electronic effects of cyrhetrene and ferrocene are not an influential factor in E1/2 and anti-Trypanosoma brucei activity for these new imines, which is probably due to the non-coplanarity of the [(η5-C5H4)-C6H4-N=CH-(C4H2S)] system.

Ethylammonium nitrate (EAN)/Tf2O and EAN/TFAA: Ionic liquid based systems for aromatic nitration

Acting as in situ sources of triflyl nitrate (TfONO2) and trifluoroacetyl nitrate (CF3COONO2), the EAN/Tf 2O and EAN/TFAA systems, generated via metathesis in the readily available ethylammonium nitrate (EAN) ionic liquid as solvent, are powerful electrophilic nitrating reagents for a wide variety of aromatic and heteroaromatic compounds. Comparative nitration experiments indicate that EAN/Tf2O is superior to EAN/TFAA for nitration of strongly deactivated systems. Both systems exhibit low substrate selectivity (K T/KB = 5-10) in (Figure presented) between values reported for covalent nitrates and preformed nitronium salts.

SMALL MOLECULE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES (PRMTS)

The present invention relates to compounds that are useful as inhibitors of protein arginine methyltransferase that have a formula selected from Formula (I), Formula (II) and Formula (III), as well as racemic mixtures, diastereomers, enantiomers and tautomers thereof and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof as defined herein. Said compound are useful as inhibitors of PRMTs and/or CARM-I. The invention further relates to compositions comprising such compounds and methods for their use.

Synthesis of the fused heterobicycles 5-pyridin-2-yl-thieno[3,2-b]pyridine, 6-pyridin-2-yl-thieno[2,3-b]pyridine and 6-pyridin-2-yl-thieno[3,2-c]pyridine

Three new pyridyl thienopyridines, 5-pyridin-2-yl-thieno[3,2-b]pyridine, 6-pyridin-2-yl-thieno[2,3-b]pyridine and 6-pyridin-2-yl-thieno[3,2-c]pyridine, have been synthesized, each through a different synthetic sequence. Overall yields ranged from 8% to 32%. Georg Thieme Verlag Stuttgart.

Cerebral antihypoxic activity of new thienyldihydropyridines

New thienyldihydropyridines were synthesized according to Hantzsch's method. The antihypoxic activity of these compounds was compared with that of three reference phenyldihydropyridines by means of the skin conductance reaction (SCR)-hypoxia test.