5752-57-8

Basic information

• Product Name: 6H-Purin-6-one, 1,7-dihydro-2-[(phenylmethyl)thio]-
• CAS NO: 5752-57-8
• Molecular Formula: C12H10N4OS
• Molecular Weight: 258.304
• Mol File: 5752-57-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 6H-Purin-6-one, 1,7-dihydro-2-[(phenylmethyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: 6H-Purin-6-one, 1,7-dihydro-2-[(phenylmethyl)thio]-(5752-57-8)
• EPA Substance Registry System: 6H-Purin-6-one, 1,7-dihydro-2-[(phenylmethyl)thio]-(5752-57-8)

Safety Data

• Hazardous Substances Data: 5752-57-8(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 2487-40-3 6-hydroxy-2-mercaptopurine 
• 122-51-0 orthoformic acid triethyl ester 
• 547740-66-9 4,5-diamino-2-phenylmethylsulfanyl-6-hydroxy-pyrimidine 
• 1002025-91-3 2-thioketo-6-keto-purine 
• 100-44-7 benzyl chloride 
• 2487-40-3 6-hydroxy-2-mercaptopurine 
• 64194-62-3 4-amino-5-formamido-6-hydroxy-2-mercaptopyrimidine 
• 547740-66-9 5,6-diamino-2-(benzylsulfanyl)-4(3H)-pyrimidinone 
• 2487-40-3 2,3-dihydro-2-thioxo-9H-purine-6(1H)-one 
• 66604-43-1 6-amino-2-(benzylsulfanyl)-5-nitroso-4(3H)-pyrimidinone 
• 37660-23-4 6-amino-2-benzylthio-3,4-dihydropyrimidin-4-one 

Downstream Products

• 135839-54-2 2-benzylthio-6-hydroxy-9-triphenylmethyl-9H-purine 
• 51998-91-5 6-chloro-2-phenylmethylsulfanylpurine 
• 51998-91-5 2-benzylmercapto-6-chloropurine 
• 1255942-71-2 2-benzylmercapto-6-(2-hydroxy-3-methoxybenzylamino)purine 
• 135839-55-3 2-benzylthio-1-methyl-9-triphenylmethyl-9H-purin-6(1H)-one 
• 135839-73-5 2-(2-hydroxyethylamino)-1-methyl-9-triphenylmethyl-9H-purin-6(1H)-one 
• 132649-18-4 (2-benzylsulfanyl-9H-purin-6-yl)-butyl-amine 
• 851370-53-1 2-(benzylsulfonyl)-6-(3-chlorophenylamino)-9-isopropylpurine 
• 851370-52-0 2-(benzylsulfanyl)-6-(3-chlorophenylamino)-9-isopropylpurine 
• 851370-50-8 6-chloro-9-isopropyl-2-phenylmethanesulfonyl-9H-purine 
• 851370-49-5 2-(benzylsulfanyl)-6-chloro-9-isopropylpurine 
• 212844-53-6 purvalanol A 

Relevant articles and documents

Substituted 6-(Benzylamino) Purine Riboside Derivatives, Use Thereof and Compositions Containing These Derivatives

The invention relates to 2-substituted-6-(substituted benzylamino)purine riboside derivatives of the general formula I. These compounds possess antiapoptotic, anti-inflammatory and differentiating activities. The invention relates also to the compositions, which contain these derivatives as active ingredients.

2-(Benzylsulfanyl)-6-chloro-9-isopropylpurine, a valuable intermediate in the synthesis of diaminopurine cyclin dependent kinase inhibitors

The synthetic potential of a novel precursor of 2,6-diaminopurine CDK inhibitors, 2-(benzylsulfanyl)-6-chloro-9-isopropylpurine, is described. The Traube purine synthesis was chosen to prepare the required 2-(benzylsulfanyl) hypoxanthine intermediate. Attempts to prepare its purin-6-yl methanesulfonic ester analogue failed. Conversion to the 6-chloropurine derivative enabled the introduction of arylamines in the presence of catalytic amounts of acid. Further chemical variety was introduced on the purine through a regioselective Mitsunobu N-9 alkylation. Oxidative cleavage of the 2-(benzylsulfanyl) leaving group with an aliphatic amine was implemented as previously reported. Purvalanol A, a potent CDK inhibitor, was synthesised using this methodology. The template and intermediates were fully characterised by modern spectroscopic techniques and single-crystal X-ray diffraction. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.

PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The invention provides certain pyrimidine compounds, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy. Formula (I) in which: A is a group of formula (a), (b) or (c).