57524-13-7

Basic information

• Product Name: α-Cyclogeranonitrile
• Synonyms: α-Cyclogeranonitrile
• CAS NO: 57524-13-7
• Molecular Formula: C₁₀H₁₅N
• Molecular Weight: 149.2328
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 57524-13-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform, Dichloromethane, Diethyl Ether, Ethyl Acetate
• CAS DataBase Reference: α-Cyclogeranonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: α-Cyclogeranonitrile(57524-13-7)
• EPA Substance Registry System: α-Cyclogeranonitrile(57524-13-7)

Safety Data

• Hazardous Substances Data: 57524-13-7(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Oil

Uses

α-Cyclogeranonitrile is used in the synthesis of Retinoic acid derivatives.

Upstream product

• 5146-66-7 geranonitrile 
• 110-93-0 6-Methyl-hept-5-en-2-on 
• 23089-87-4 5-methyl-4-hexenenitrile 
• 5585-39-7 (E)-3,7-dimethylocta-2,6-dienenitrile 
• 145106-55-4 (1S,2R,5S) 1-(1-Methylethyl)-2,4,4-trimethylbicyclo<3.1.0>hexan-3-one 
• 145106-57-6 (1S,2S,5S) 1-(1-Methylethyl)-2,4,4-trimethylbicyclo<3.1.0>hexan-3-one 
• 103324-66-9 1-hydroxy-2,2,6-trimethyl-cyclohexanecarbonitrile 
• 2408-37-9 2,2,6-trimethylcyclohexan-1-one 
• 57524-14-8 2,2,6-trimethyl-1-cyclohexenylcarbonitrile 
• 56830-39-8 2,4,4-Trimethylcyclohex-2-en-1-one-3-carbonitrile 
• 145106-79-2 3-hydroxy-2,6,6-trimethylcyclohex-1-enecarbonitrile 
• 78887-20-4 (1S,5S) 4,4-Dimethyl-1-(1-methylethyl)-bicyclo<3.1.0>hexan-3-one 

Downstream Products

• 264279-20-1 2,3-epoxy-2,6,6-trimethyl-1-cyclohexanecarbonitrile 
• 7542-45-2 3,3'-dihydroxy-β,β-carotene-4,4'-dione 
• 29538-78-1 (2E,4E)-3-methyl-5-(2,6,6-trimethyl-3-oxo-1-cyclohexen-1-yl)-2,4-pentadienol 
• 56830-39-8 2,4,4-Trimethylcyclohex-2-en-1-one-3-carbonitrile 
• 94669-81-5 (E)-6-Hydroxy-3-(5-hydroxy-3-methyl-1,3-pentadienyl)-2,4,4-trimethyl-2-cyclohexen-1-on 
• 80736-89-6 (2E,4E)-1-bromo-3-methyl-5-(4-hydroxy-2,6,6-trimethyl-3-oxo-1-cyclohexen-1-yl)-2,4-pentadiene 
• 6890-91-1 (3RS,all-E)-hydroxyretinal 
• 7584-74-9 C₂₀H₂₈O₂ 
• 145106-79-2 3-hydroxy-2,6,6-trimethylcyclohex-1-enecarbonitrile 

Relevant articles and documents

COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS

A method of treating an ocular disorder in a subject associated with increased all-trans-retinal in an ocular tissue includes administering to the subject a therapeutically effective amount of a primary amine compound of formula (I); and pharmaceutically acceptable salts thereof.

Synthesis and characterization of all-E-(4,4'-13C2)-astaxanthin strategies for labelling the C15-end groups of carotenoids

The all-E isomer of (4,4'-13C2)astaxanthin (1a) has been prepared by total synthesis starting from commercially available 99% 13C enriched acetonitrile. The labelled astaxanthin was obtained in high purity and with high isotope incorporation. For this synthesis, the C15 + C10 + C15 strategy was used. The central C10-synthon, 2,7-dimethylocta-2,4,6-triene- 1,8-dial (3), was coupled with 13C-enriched C15-phosphonium salt 2a. The new synthetic scheme for the preparation of the C15-phosphonium salt is discussed in this paper; the same scheme can be used to label all positions and combinations of positions of the C15-phosphonium salt.

The chemistry of thujone. XVI. Versatile and efficient routes to safronitrile, β-cyclogeranonitrile, β-cyclocitral, damascones, and their analogues

Thujone, a waste by-product of the Canadian forest industry, has been utilized as a starting material to develop a versatile synthetic route to the damascones (rose oil ketones) and related analogues.The synthetic sequence provides a route to β-cyclocitral (45), the latter having been previously converted to β-damascone (2).In addition, thujone-drived intermediates are converted to β-damascenone (48) and to intermediates that can be utilized for the preparation of damascone analogues.In conjunction with the above, an efficient route to safronitrile (42), β-cyclogeranonitrile (43), and β-cyclocitral (45) from 2,6-dimethylcyclohexanone has been developed.In summary, these studies afford an attractive versatile route to these important perfumery materials.