57539-95-4Relevant academic research and scientific papers
Cu-Catalyzed Alkynylation of Unactivated C(sp3)-X Bonds with Terminal Alkynes through Directing Strategy
Luo, Fei-Xian,Xu, Xing,Wang, Ding,Cao, Zhi-Chao,Zhang, Yun-Fei,Shi, Zhang-Jie
, p. 2040 - 2043 (2016)
In this letter, we report an efficient and concise protocol for Cu-catalyzed cross-coupling of unactivated alkyl halides/peusudohalides with terminal alkynes to afford internal alkynes with the assistance of various amides as directing groups. Different alkyl halides/pseudohalides exhibited excellent reactivities, and the inactivated alkyl chlorides and sulfonates showed better reactivity than bromides/iodides. This is the first successful example to apply alkyl chlorides and sulfonates directly in cross-coupling with terminal alkynes in the absence of any additives. A Cu catalyst was found to be more effective than other transition metal catalysts. This reaction also exhibited a broad substrate scope with respect to terminal alkynes.
Preparation of 2,2-disubstituted 3-chloropropionic esters
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, (2008/06/13)
2,2-Disubstituted 3-chloropropionic esters I STR1 where R1 and R2 are each C1 -C6 -alkyl, C2 -C6 -oxaalkyl, C2 -C6 -alkenyl, C2 -C6 -oxaalkenyl,
