57543-47-2Relevant articles and documents
A chromene pyrazoline derivatives fluorescent probe for Zn2+ detection in aqueous solution and living cells
Zhang, Ying-Peng,Xue, Qing-Hua,Yang, Yun-Shang,Liu, Xiao-Yu,Ma, Chun-Mei,Ru, Jia-Xi,Guo, Hui-Chen
, p. 128 - 134 (2018)
A new chromene pyrazoline derivatives fluorescent probe L was designed and synthesized. The probe L appears in a 55-fold fluorescence enhancement after 5 equiv. Zn2+ was added, and it also exhibits high sensitivity and selectivity for response
One-pot pyrrolidine-catalyzed synthesis of benzopyrans, benzothiopyranes, and dihydroquinolidines
Ibrahem, Ismail,Sunden, Henrik,Rios, Ramon,Zhao, Gui-Ling,Cordova, Armando
, p. 219 - 223 (2007)
A simple catalytic racemic synthesis of benzopyranes, benzothiopyranes and 1,2-dihydroquinolines is presented. The organocatalytic domino reactions between 2-heteroatom substituted aldehyde derivatives and α,β-unsaturated aldehydes or α,β-unsaturated cycl
Enantioselective organocatalytic synthesis of the chiral chromenes by domino oxa-Michael-aldol reaction
Pendalwar, Shrikant S.,Chakrawar, Avinash V.,Bhusare, Sudhakar R.
, p. 942 - 944 (2017/10/23)
The proline based chiral organocatalyst has been found to be an efficient catalyst for the facile synthesis of substituted 2-aryl-2H-chromenes-3-carbaldehyde. We envisioned that the iminium interaction between chiral amino catalysts and α,β-unsaturated ca
Diastereoselective synthesis of novel spiro indanone fused pyrano[3,2-: c] chromene derivatives following hetero-Diels-Alder reaction and in vitro anticancer studies
Panda, Pravati,Nayak, Sabita,Sahoo, Susanta Ku.,Mohapatra, Seetaram,Nayak, Deepika,Pradhan, Rajalaxmi,Kundu, Chanakya Nath
, p. 16802 - 16814 (2018/05/23)
The development of concise methods for the synthesis of small functionalised spirocyclic molecules is important in the search of new bioactive molecules. To contribute this, here we represent a diastereoselective oxa-hetero-Diels-Alder reaction for the synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives and studied their in vitro anticancer activities. Using previously less explored cyclic ketone i.e. indane-1,3-dione and 3-vinyl-2H-chromene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products. Various spiro indanone fused pyrano[3,2-c]chromene derivatives were synthesized regiospecifically bearing a quaternary stereocenter in high yields (up to 85%) with excellent diastereoselectivity in toluene using 4 ? MS as additive under reflux condition at 120 °C. In vitro cytotoxic studies of these compounds against MCF-7 (breast cancer), HCT-116 (colon cancer), H-357 (oral cancer), MD-MB-231(Breast cancer) cell lines were evaluated by MTT {3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide} assay in vitro. The screening results revealed that many of the compounds are showing moderate to high levels of anticancer activities against the tested cancer cell lines and some displayed potent inhibitory activities in comparison to the commercial anticancer drug 5-fluorouracil (5-FU). Among the series, compound 3′c showed most potent cytotoxicity (15.0-27.5 μM) in three cancer cell lines (MCF-7, HCT-116 and MD-MB-231).