575465-48-4Relevant academic research and scientific papers
Diastereoselective intermolecular addition of the 1,3-dioxolanyl radical to N-acyl aldohydrazones. Asymmetric synthesis of α-amino acid derivatives
Fernandez, Marta,Alonso, Ricardo
, p. 2461 - 2464 (2003)
(Matrix presented) N-Acyl aldohydrazones I (R = CO2Et, alkyl, aryl, and furyl) efficiently trap the 1,3-dioxolanyl radical intermolecularly without external activation at temperatures as low as -78°C. For alkyl aldohydrazones, good diastereoselectivities are obtained in the presence of InCl3 at low temperature. Elaboration of the adducts (II) allows for the asymmetric synthesis of α-amino acid derivatives.
