57556-31-7Relevant articles and documents
NEW ISOINDOLINONE SUBSTITUTED INDOLES AND DERIVATIVES AS RAS INHIBITORS
-
Page/Page column 48-49, (2020/09/12)
-The present invention relates to new isoindolinone or isobenzofuranone substituted indoles and derivatives of formula (I) wherein the groups R1 to R7, R10 and n have the meanings given in the claims and specification, their use as inhibitors of RAS-family proteins and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.
Oligonucleotide with protected base
-
Page/Page column 71, (2016/07/27)
The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3′-position.
METHOD OF MANUFACTURING 4-HYDROXY-2-METHYLBENZOIC ACID DERIVATIVE
-
Paragraph 0044-0045; 0047-0048, (2016/11/17)
PROBLEM TO BE SOLVED: To provide a method for manufacturing 4-hydroxy-2-methylbenzoic esters simply in a short time. SOLUTION: There is provided a method for manufacturing a 4-hydroxy-2-methylbenzoic acid derivative (1) by air oxidizing a 2-methyl-4-oxo-2