57556-31-7

Usage

Uses

Used in Cosmetic and Personal Care Industry:
Methyl 4-hydroxy-2-methylbenzoate is used as a preservative for its antimicrobial properties, effectively preventing the growth of bacteria and fungi in skincare and haircare products, thereby enhancing their shelf life and safety for consumers.
Used in Pharmaceutical Industry:
In pharmaceutical formulations, Methyl 4-hydroxy-2-methylbenzoate serves as a preservative to maintain the sterility and stability of medications, ensuring their efficacy and safety for patients.
Used in Food Industry:
Methyl 4-hydroxy-2-methylbenzoate is used as a flavoring agent in food products, contributing to the enhancement of taste and aroma profiles, making the food items more appealing to consumers.
Used in Perfumery and Fragrance Industry:
As a fragrance ingredient, Methyl 4-hydroxy-2-methylbenzoate is utilized in perfumes and other scented items to provide a pleasant and lasting scent, adding value to these products.
It is crucial to use Methyl 4-hydroxy-2-methylbenzoate with caution and in accordance with safety guidelines to minimize potential health risks.

InChI:InChI=1/C9H10O3/c1-6-5-7(10)3-4-8(6)9(11)12-2/h3-5,10H,1-2H3

Upstream product

• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 133921-27-4 4-iodo-3-methyl-phenol 
• 108-39-4 3-methyl-phenol 
• 35490-07-4 methyl 2-methyl-4-oxocyclohex-2-enecarboxylate 
• 186581-53-3 diazomethane 
• 578-39-2 4-hydroxy-2-methylbenzoic acid 
• 63446-76-4 1-methyl-1,3-bis(trimethylsilyloxy)buta-1,3-diene 
• 922-67-8 propynoic acid methyl ester 
• 14143-26-1 4-hydroxy-2-methylbenzonitrile 

Downstream Products

• 104216-19-5 4-ethoxy-2-methyl-benzoic acid methyl ester 
• 1040723-95-2 4-cyclopropylmethoxy-2-methyl-benzoic acid methyl ester 
• 1204301-92-7 4-[3-(4-methoxycarbonyl-3-methylphenoxy)propyl]piperidine-1-carboxylic acid tert-butyl ester 
• 103323-97-3 4-ethoxy-2-methyl-benzoic acid 
• 1416990-20-9 methyl 4-acetoxy-2-methylbenzoate 
• 875895-67-3 methyl 2-(bromomethyl)-4-hydroxybenzoate 
• 2375482-51-0 5-hydroxy-3-[2-({[1-(1-methyl-1H-imidazol-4-ylmethyl)-1H-indol-6-ylmethyl]amino}methyl)-1H-indol-3-yl]-2,3-dihydroisoindol-1-one 
• 2375482-51-0 (S)-5-hydroxy-3-[2-({[1-(1-methyl-1H-imidazol-4-ylmethyl)-1H-indol-6-ylmethyl]amino}methyl)-1H-indol-3-yl]-2,3-dihydroisoindol-1-one 
• 2375482-51-0 (R)-5-hydroxy-3-[2-({[1-(1-methyl-1H-imidazol-4-ylmethyl)-1H-indol-6-ylmethyl]amino}methyl)-1H-indol-3-yl]-2,3-dihydroisoindol-1-one 

Relevant academic research and scientific papers

NEW ISOINDOLINONE SUBSTITUTED INDOLES AND DERIVATIVES AS RAS INHIBITORS

-The present invention relates to new isoindolinone or isobenzofuranone substituted indoles and derivatives of formula (I) wherein the groups R1 to R7, R10 and n have the meanings given in the claims and specification, their use as inhibitors of RAS-family proteins and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.

Palladium-Catalyzed Aerobic Oxidative Carbonylation of C–H Bonds in Phenols for the Synthesis of p-Hydroxybenzoates

This work reports the synthesis of p-hydroxybenzoates directly from phenols by oxidative carbonylation of phenolic C–H bonds, proceding through oxidative iodination. The developed methodology is efficient and economically attractive because phenols are cheap and easily available starting materials. This one-pot strategy was expediently applied to the synthesis of a variety of p-hydroxybenzoates by utilizing simple primary and secondary alcohols with different phenols under mild reaction conditions. Advantageously, the procedure has no need for co-catalysts, co-solvents or external ligands. The utilization of molecular oxygen as a terminal oxidant for C–H bond oxidation represents an additional benefit.

A highly efficient metal-free approach to: Meta - And multiple-substituted phenols via a simple oxidation of cyclohexenones

A novel and efficient metal-free approach to substituted phenols has been disclosed from simple and readily available cyclohexenones and cyclohexenone equivalents. Dimethyl sulfoxide (DMSO), a simple and common organic reagent, was employed as a mild oxidant in this I2-catalysis, which significantly tolerates various substituents including some easily oxidizable or reducible functionalities. The challenging meta- and multiple-substituted phenols could be well prepared by this method. The metal-free and mild oxidation make this protocol very simple, practical, and easy to handle.

Oligonucleotide with protected base

The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3′-position.

METHOD OF MANUFACTURING 4-HYDROXY-2-METHYLBENZOIC ACID DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method for manufacturing 4-hydroxy-2-methylbenzoic esters simply in a short time. SOLUTION: There is provided a method for manufacturing a 4-hydroxy-2-methylbenzoic acid derivative (1) by air oxidizing a 2-methyl-4-oxo-2

BASE-PROTECTED OLIGONUCLEOTIDE

The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3'-position.

AROMATIC COMPOUND CONTAINING SPECIFIC BRANCH

The present invention provides a particular branched chain-containing aromatic compound. The branched chain-containing aromatic compound of the present invention is easily-soluble in isopropyl acetate superior in liquid-separation operability, and can be used for a production method of peptide and the like, which provides a final product simply by extraction separation, without crystallization and isolation of each intermediate in each step.

BRANCHED CHAIN-CONTAINING AROMATIC COMPOUND

[Summary] [Problem] Provision of a novel compound which is easily-soluble in isopropyl acetate superior in liquid-separation operability, and can be used for a production method of peptide and the like, that provides a final product simply by extraction-l

The power of solvent in altering the course of photorearrangements

A clean bifurcation between two important photochemical reactions through competition of a triplet state Type II H-abstraction reaction with a photo-Favorskii rearrangement for (o/p)-hydroxy-o-methylphenacyl esters that depends on the water content of the solvent has been established. The switch from the anhydrous Type II pathway that yields indanones to the aqueous-dependent pathway producing benzofuranones occurs abruptly at low water concentrations (～8%). The surprisingly clean yields suggest that such reactions are synthetically promising.

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS

The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can a