57584-95-9Relevant academic research and scientific papers
1H, 13C and 15N NMR spectral analysis of substituted 1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidines
Girreser, Ulrich,Bluhm, Ullvi,Clement, Bernd,Heber, Dieter
, p. 714 - 721 (2013)
The NMR spectroscopic data of a series of thirty-four 3-acylpyrido[1,2-a] pyrimidinium salts are analyzed, which were prepared as either perchlorates or chlorides. Methyl group substituted 3-aroyltetrahydropyrido[1,2-a]pyrimidines with the methyl substituent in positions 6, 8 and 9 as well as both in positions 6 and 8 were investigated bearing various aroyl substituents. Unequivocal assignment of all resonances was achieved via two-dimensional 1H,1H-COSY measurements, 1H,13C and 1H,15N HSQC as well as HMBC experiments, and important diagnostic CH and NH couplings in the heteroaromatic ring system are evaluated. The influence of the methyl substituents was analyzed on the proton, carbon and nitrogen shifts. A significant effect of the counter ion on some chemical shifts of the nuclei under discussion of the pyridopyrimidines is found, allowing the indirect detection of the anion, which is confirmed by direct measurement of the 35Cl nucleus of the perchlorates. Copyright 2013 John Wiley & Sons, Ltd. The 1H, 13C and 15N NMR spectroscopic data of a series of thirty-four 3-acylpyrido[1,2-a]pyrimidinium salts are analyzed, which were prepared as either perchlorates or chlorides They contain methyl substituent(s) in positions 6, 8 and 9 as well as both in positions 6 and 8. Important CH and NH long range couplings and significant differences of the chemical shifts depending on either the position of the methyl group or the counter ion were evaluated. Copyright
Fe-catalyzed bisphosphorylation of amino-2-en-1-ones with trialkyl Phosphites
Guo, Shengmei,Jie, Kun,Huang, Ling,Zhang, Zhebin,Wang, Yufeng,Fu, Zhengjiang,Cai, Hu
supporting information, p. 1090 - 1094 (2019/05/27)
A facile bisphosphorylation of amino-2-en-1-ones with trialkyl phosphites mediated by iron is developed. The reaction is considered to go through two Michael addition progresses. A variety of amino-2-en-1-ones are bisphosphorylated in high yields with functional group tolerance. In addition, the protocol of introduction of two different phosphates into one molecule is successful through a cascade reaction.
Amino dithio-formic acid ally propyl ester compound and its preparation and use
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Paragraph 0045; 0047; 0048, (2017/10/06)
The present invention relates to a compound represented by a general formula (I) or a pharmaceutically acceptable salt or solvate thereof, a preparation method of the compound, and uses of the compound in preparation of antitumor drugs. The formula I is defined in the specification.
Synthesis of pyrimidine and 1,3-bishydroxylamine derivatives from enone Mannich base methiodides
Khlestkin, Vadim K.,Tikhonov, Alexsei Ya.
, p. 249 - 254 (2007/10/03)
Reaction of the bis(aminomethylated) alkylaromatic ketones with methyl iodide gave the enone Mannich base methiodides. Subsequent reaction with two equivalents of methoxyamine or sodium anti-benzaldoximate resulted in 1,3-bismethoxyamine or dinitrone correspondingly. Partial hydroxylaminolyses of dinitrones led to 5-aroyl-1,3-dihydroxy-2-phenylperhydropyrimidines. Reaction of the enone Mannich base methiodides with cyclic paramagnetic amidine gave nitroxides of imidazopyrimidine series.
