57592-43-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluorobiphenyl-4-carboxaldehyde 97 is used as a starting material for the synthesis of (2-fluoro-1,1′-biphenyl-4-yl)acetic acid, a novel unsubstituted flurbiprofen (FLU) derivative. This derivative has potential applications in the development of new drugs, particularly in the area of anti-inflammatory and analgesic medications, due to the known properties of flurbiprofen.
Used in Chemical Synthesis:
As an oxygen-containing polycyclic aromatic hydrocarbon derivative, 2-Fluorobiphenyl-4-carboxaldehyde 97 can be utilized in various chemical synthesis processes. Its unique structure allows for the creation of a wide range of compounds with different properties and applications, making it a valuable building block in the chemical industry.
Used in Research and Development:
The distinct chemical properties of 2-Fluorobiphenyl-4-carboxaldehyde 97 make it an interesting compound for research and development purposes. Scientists and researchers can explore its potential applications in various fields, such as materials science, pharmaceuticals, and chemical engineering, by studying its reactivity, stability, and interactions with other compounds.

InChI:InChI=1/C13H9FO/c14-13-8-10(9-15)6-7-12(13)11-4-2-1-3-5-11/h1-9H

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 133059-43-5 4-bromo-3-fluorobenzaldehyde 
• 98-80-6 phenylboronic acid 
• 50-00-0 formaldehyd 
• 41604-19-7 1-bromo-3-fluoro-4-phenylbenzene 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 5001-96-7 2-(2-fluoro-[1,1'-biphenyl]-4-yl)acetic acid 
• 1361001-64-0 sodium (E)-2-(1-((2-fluoro-[1,1'-biphenyl]-4-yl)methylene)-5-methoxy-1H-inden-3-yl)acetate 
• 1361000-86-3 (E)-2-(5-fluoro-1-((2-fluorobiphenyl-4-yl)methylene)-1H-inden-3-yl)acetic acid 
• 1361001-10-6 (E)-ethyl 2-(5-fluoro-1-((2-fluoro-[1,1'-biphenyl]-4-yl)methylene)-1H-inden-3-yl)-2-methyl propanoate 
• 216701-21-2 (2-fluoro-[1,1’-biphenyl]-4-yl)methanol 

Relevant academic research and scientific papers

Alkyl Carbagermatranes Enable Practical Palladium-Catalyzed sp2-sp3 Cross-Coupling

Pd-catalyzed cross-coupling reactions have achieved tremendous accomplishments in the past decades. However, C(sp3)-hybridized nucleophiles generally remain as challenging coupling partners due to their sluggish transmetalation compared to the C(sp2)-hybridized counterparts. While a single-electron-transfer-based strategy using C(sp3)-hybridized nucleophiles had made significant progress recently, fewer breakthroughs have been made concerning the traditional two-electron mechanism involving C(sp3)-hybridized nucleophiles. In this report, we present a series of unique alkyl carbagermatranes that were proven to be highly reactive in cross-coupling reactions with our newly developed electron-deficient phosphine ligands. Generally, secondary alkyl carbagermatranes show slightly lower, yet comparable activity to its Sn analogue. Meanwhile, primary alkyl carbagermatranes exhibit high activity, and they were also proved stable enough to be compatible with various reactions. Chiral secondary benzyl carbagermatrane gave the coupling product under base/additive-free conditions with its configuration fully inversed, suggesting that transmetalation was carried out in an "SE2(open) Inv" pathway, which is consistent with Hiyama's previous observation. Notably, the cross-coupling of primary alkyl carbagermatranes could be performed under base/additive-free conditions with excellent functional group tolerance and therefore may have potentially important applications such as stapled peptide synthesis.

Alkylimidazole-Based Phosphines as Efficient Ligands for Palladium-Catalyzed Suzuki Reactions

Two series of alkylimidazole-based phosphines were conveniently synthesized in one step from the corresponding alkylimidazole by selective deprotonation and quenching with chlorodiphenylphosphine. The novel ligands are easily tunable and exhibit good-to-excellent performance in the palladium-catalyzed Suzuki coupling reaction.

Catalytic activity of 1-methylimidazole-based phosphine ligands in the palladium-catalyzed Suzuki coupling reaction

The catalytic activities of three N-methylimidazole-based phosphine ligands in the Suzuki coupling reaction were tested using PdCl2 as the catalyst. The results showed all three phosphine ligands exhibited excellent activity towards the Suzuki reaction, and the catalytic activity decreased with increasing number of imidazole groups.

Palladium-catalyzed carbonylations of aryl bromides using paraformaldehyde: Synthesis of aldehydes and esters

Carbonylation reactions represent useful tools for organic synthesis. However, the necessity to use gaseous carbon monoxide is a disadvantage for most organic chemists. To solve this problem, novel protocols have been developed for conducting palladium-catalyzed reductive carbonylations of aryl bromides and alkoxycarbonylations using paraformaldehyde as an external CO source (CO gas free). Hence, aromatic aldehydes and esters were synthesized in moderate to good yields.

A new method for the preparation of microcapsule-supported palladium catalyst for Suzuki coupling reaction

In this paper, a new method for the preparation of microcapsule-supported palladium catalyst for Suzuki coupling reaction was described. The highly monodispersed cross-linked polystyrene microcapsules containing phosphine ligand were synthesized by the se

Compositions and methods of treating cell proliferation disorders

The invention relates to compounds and methods for treating cell proliferation disorders.

Comparison of the Properties of Liquid Crystals Derived from Certain Lateral Halogeno-substituted Azomethines

Twenty-eight 4-n-alkoxy-N-(2- and 2'-halogenobiphenyl-4-ylmethylene)anilines comprising 4,8,8,4, and 4 members derived , respectively, from 2-fluoro-, 2'-fluoro-, 2'-chloro-, 2'-bromo-, and 2'-iodo-biphenyl-4-carbaldehyde, together with six 4-p-n-alkoxy-2'-fluorobenzylideneaminobiphenyls have been prepared.The liquid crystal behaviour of these compounds has been compared with analogous azomethines with reversed CH=N linkage, previously reported.