57600-76-7

Basic information

• Product Name: 4-chloro-2',4'-dimethoxybenzophenone
• Synonyms: 4-chloro-2',4'-dimethoxybenzophenone
• CAS NO: 57600-76-7
• Molecular Weight: 276.719
• Mol File: 57600-76-7.mol

Chemical Properties

• CAS DataBase Reference: 4-chloro-2',4'-dimethoxybenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2',4'-dimethoxybenzophenone(57600-76-7)
• EPA Substance Registry System: 4-chloro-2',4'-dimethoxybenzophenone(57600-76-7)

Safety Data

• Hazardous Substances Data: 57600-76-7(Hazardous Substances Data)

Upstream product

• 111122-91-9 2-(4-Chloro-phenyl)-2-(2,4-dimethoxy-phenyl)-benzo[1,3]oxathiole 
• 122-01-0 4-chloro-benzoyl chloride 
• 151-10-0 1,3-Dimethoxybenzene 
• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 
• 104-88-1 4-chlorobenzaldehyde 
• 58948-38-2 2-(4-Chlorophenyl)-1,3-benzoxathiolium tetrafluoroborate 
• 111122-90-8 2-(2,4-Dimethoxy-phenyl)-2-phenyl-benzo[1,3]oxathiole 

Downstream Products

• 18239-10-6 2,4-dihydroxy-4'-chlorobenzophenone 
• 945663-27-4 (4-(8-bromooctyloxy)-2-hydroxyphenyl)(4-chlorophenyl)methanone 
• 945663-32-1 (E)(4-(4-(3-bromopropoxy)but-2-enyloxy)-2-hydroxyphenyl)(4-chlorophenyl)methanone 
• 945663-31-0 (E)-(4-chlorophenyl)(2-hydroxy-4-(4-(3-hydroxypropoxy)but-2-enyloxy)phenyl)methanone 
• 945663-30-9 (E)-(4-(4-bromobut-2-enyloxy)-2-hydroxyphenyl)(4-chlorophenyl)methanone 

Relevant articles and documents

Facile preparation of aromatic ketones from aromatic bromides and arenes with aldehydes

Aromatic ketones were efficiently prepared in good yields by the reactions of aryl bromides with n-BuLi, followed by the reactions with aromatic aldehydes or aliphatic aldehydes and the subsequent treatment with molecular iodine and K2CO3, in a one-pot method. The same treatment of arenes, instead of aromatic bromides, also provided the corresponding aromatic ketones in good yields. Using these methods, various diaryl ketones and alkyl aryl ketones bearing electron-rich aromatics and electron-deficient aromatics could be prepared efficiently by a simple, transition-metal-free, and therefore environmentally benign experimental procedure.

COMPOSITIONS AND METHODS OF USE OF ELECTRON TRANSPORT SYSTEM INHIBITORS

The invention provides compounds of the formula: or a pharmaceutically acceptable salt thereof, where m, n, R1, R2, R3 R4, R5, R6, R7 are those defined herein. The invention also provides pharmaceutical compositions comprising a compound of the invention, methods for using compounds and/or pharmaceutical compositions of the invention, and methods for synthesizing compounds of the invention.

Discovery of 1,4-didydroxy-2-naphthoate prenyltransferase inhibitors: New drug leads for multidrug-resistant gram-positive pathogens

Since utilization of menaquinone in the electron transport system is a characteristic of Gram-positive organisms, the 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) inhibitors 1a and 2a act as selective antibacterial agents against organisms such as methicillin-resistant Stapylococcus aureus (MRSA), Staphylococcus epidermidis (MRSE), and Mycobacterium spp. Growth of drug-resistant Gram-positive organisms was sensitive to the MenA inhibitors, indicating that menaquinone synthesis is a valid new drug target in Gram-positive organisms.

2-Substituted 1,3-Benzoxathiolium Tetrafluoroborates as Useful Acylating Agents of Electron-Rich Aromatic and Heteroaromatic Compounds

2-Substituted 1,3-benzoxathiolium tetrafluoroborates were used for the two-step acylation of electron-rich aromatic and heteroaromatic compounds: 1,3-dimethoxybenzene, 1,3,5-trimethoxybenzene, pyrrole and indoles.In most of the cases intermediate 2,2-disubstituted 1,3-benzoxathioles were obtained in good to high yields (55-100percent) and subsequent hydrolysis of these with mercury(II) oxide and aqueous tetrafluoroboric acid (35percent) in tetrahydrofuran afforded the corresponding ketones in almost quantitative yields.