57626-46-7 Usage
Uses
Used in Pharmaceutical Synthesis:
(6-PHENYL-IMIDAZO[2,1-B]THIAZOL-3-YL)-ACETIC ACID ETHYL ESTER is used as a key intermediate in the synthesis of pharmaceutical drugs. Its unique structure and properties make it a valuable building block for the development of new drugs with potential therapeutic benefits.
Used in Organic Chemistry:
In the field of organic chemistry, (6-PHENYL-IMIDAZO[2,1-B]THIAZOL-3-YL)-ACETIC ACID ETHYL ESTER serves as a versatile compound for the synthesis of various organic compounds. Its structural features allow for further functionalization and modification, enabling the creation of a wide range of chemical products with diverse applications.
Used in Drug Development:
(6-PHENYL-IMIDAZO[2,1-B]THIAZOL-3-YL)-ACETIC ACID ETHYL ESTER is used as a starting material in drug development, particularly for the creation of novel therapeutic agents. Its unique chemical structure and properties make it an attractive candidate for the design and synthesis of new drugs with improved efficacy and selectivity.
Used in Chemical Research:
In the realm of chemical research, (6-PHENYL-IMIDAZO[2,1-B]THIAZOL-3-YL)-ACETIC ACID ETHYL ESTER is employed as a model compound for studying various chemical reactions and mechanisms. Its structural complexity and reactivity provide valuable insights into the behavior of similar compounds and contribute to the advancement of chemical knowledge.
Used in the Chemical Industry:
(6-PHENYL-IMIDAZO[2,1-B]THIAZOL-3-YL)-ACETIC ACID ETHYL ESTER is utilized in the chemical industry for the production of various specialty chemicals and materials. Its unique properties make it suitable for a range of applications, from the synthesis of advanced materials to the development of new chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 57626-46-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,6,2 and 6 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 57626-46:
(7*5)+(6*7)+(5*6)+(4*2)+(3*6)+(2*4)+(1*6)=147
147 % 10 = 7
So 57626-46-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H14N2O2S/c1-2-19-14(18)8-12-10-20-15-16-13(9-17(12)15)11-6-4-3-5-7-11/h3-7,9-10H,2,8H2,1H3
57626-46-7Relevant academic research and scientific papers
Synthesis and cytotoxic activity of some novel N-pyridinyl-2-(6- phenylimidazo[2,1-b]thiazol-3-yl)acetamide derivatives
Ding, Huaiwei,Chen, Zhe,Zhang, Cunlong,Xin, Tian,Wang, Yini,Song, Hongrui,Jiang, Yuyang,Chen, Yuzong,Xu, Yongnan,Tan, Chunyan
experimental part, p. 4703 - 4716 (2012/07/01)
A series of novel compounds bearing imidazo[2,1-b]thiazole scaffolds were designed and synthesized based on the optimization of the virtual screening hit compound N-(6-morpholinopyridin-3-yl)-2-(6-phenylimidazo[2,1-b]thiazol-3-yl) acetamide (5a), and tested for their cytotoxicity against human cancer cell lines, including HepG2 and MDA-MB-231. The results indicated that the compound 2-(6-(4-chlorophenyl)imidazo [2,1-b]thiazol-3-yl)-N-(6-(4-(4-methoxybenzyl) piperazin-1-yl)pyridin-3-yl)acetamide (5l), with slightly higher inhibition on VEGFR2 than 5a (5.72% and 3.76% inhibitory rate at 20 μM, respectively), was a potential inhibitor against MDA-MB-231 (IC50 = 1.4 μM) compared with sorafenib (IC50 = 5.2 μM), and showed more selectivity against MDA-MB-231 than HepG2 cell line (IC50 = 22.6 μM).
Substituted imidazo[2,1-b]thiazoles from 2-aminothiazoles and α-bromo ketones: Efficient preparation and proof of structure
Meakins, G. Denis,Musk, Sally R. R.,Robertson, Colin A.,Woodhouse, Lee S.
, p. 643 - 648 (2007/10/02)
The salts formed from α-aminothiazoles and α-bromo ketones (RCOCH2Br) have been basified, and the products converted into amides. Examination of the amides established that they are 2-acylimino-2,3- dihydrothiazoles rather than 2-acylaminothiaz
