(6-PHENYL-IMIDAZO[2,1-B]THIAZOL-3-YL)-ACETIC ACID ETHYL ESTER

Base Information

• Chemical Name: (6-PHENYL-IMIDAZO[2,1-B]THIAZOL-3-YL)-ACETIC ACID ETHYL ESTER
• CAS No.: 57626-46-7
• Molecular Formula: C15H14 N2 O2 S
• Molecular Weight: 286.3489
• Mol file: 57626-46-7.mol

Synonyms:Ethyl6-phenylimidazo[2,1-b]thiazole-3-acetate; NSC 367338

Chemical Property of (6-PHENYL-IMIDAZO[2,1-B]THIAZOL-3-YL)-ACETIC ACID ETHYL ESTER

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 71.84000
• Density: 1.29g/cm³
• LogP: 3.16840

Purity/Quality:

6-PHENYLIMIDAZO[2,1-B]THIAZOLE-3-ACETIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-PHENYL-IMIDAZO[2,1-B]THIAZOL-3-YL)-ACETIC ACID ETHYL ESTER

There total 8 articles about (6-PHENYL-IMIDAZO[2,1-B]THIAZOL-3-YL)-ACETIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-ethoxycarbonylmethyl-6-phenyl-7H-imidazo<2,1-b>thiazolium bromide → 3-ethoxycarbonylmethyl-6-phenylimidazo<2,1-b>thiazole (57626-46-7)

Guidance literature:

With sodium carbonate; In chloroform; at 20 ℃; for 0.333333h;

Reference yield: 45.8%

ethyl 2-amino-1,3-thiazol-4-acetate (53266-94-7) + α-bromoacetophenone (70-11-1) → 3-ethoxycarbonylmethyl-6-phenylimidazo<2,1-b>thiazole (57626-46-7)

Guidance literature:

In ethanol; for 8h; Heating;

DOI:10.1016/0223-5234(96)88309-7

Reference yield:

ethyl 2-amino-1,3-thiazol-4-acetate (53266-94-7) → 3-ethoxycarbonylmethyl-6-phenylimidazo<2,1-b>thiazole (57626-46-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / acetone / 24 h / 20 °C

2: 59 percent / 1M aq. NaHCO₃ / CHCl₃ / 0.33 h / 20 °C

3: ethanol / 1 h / Heating

With sodium hydrogencarbonate; In ethanol; chloroform; acetone;

upstream raw materials:

4-ethoxycarbonylmethyl-2-imino-3-phenacyl-2,3-dihydrothiazole

2-amino-4-ethoxycarbonylmethyl-3-(2-oxo-2-phenyl-ethyl)-thiazolium; bromide

ethyl 2-amino-1,3-thiazol-4-acetate

α-bromoacetophenone

Downstream raw materials:

(6-phenylimidazo[2,1-b]thiazol-3-yl)acetic acid hydrazide