940794-02-5

Basic information

• Product Name: N-(6-morpholinopyridin-3-yl)-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide
• Synonyms: N-(6-morpholinopyridin-3-yl)-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide
• CAS NO: 940794-02-5
• Molecular Weight: 419.507
• Mol File: 940794-02-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(6-morpholinopyridin-3-yl)-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-morpholinopyridin-3-yl)-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide(940794-02-5)
• EPA Substance Registry System: N-(6-morpholinopyridin-3-yl)-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide(940794-02-5)

Safety Data

• Hazardous Substances Data: 940794-02-5(Hazardous Substances Data)

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 53266-94-7 ethyl 2-amino-1,3-thiazol-4-acetate 
• 52023-68-4 6-(morpholin-4-yl)pyridin-3-amine 
• 68347-91-1 6-phenylimidazo<2,1-b>thiazole-3-acetic acid 
• 26820-62-2 4-(5-nitro-pyridin-2-yl)-morpholine 
• 57626-46-7 3-ethoxycarbonylmethyl-6-phenylimidazo<2,1-b>thiazole 
• 70-11-1 α-bromoacetophenone 

Relevant articles and documents

Synthesis and cytotoxic activity of some novel N-pyridinyl-2-(6- phenylimidazo[2,1-b]thiazol-3-yl)acetamide derivatives

A series of novel compounds bearing imidazo[2,1-b]thiazole scaffolds were designed and synthesized based on the optimization of the virtual screening hit compound N-(6-morpholinopyridin-3-yl)-2-(6-phenylimidazo[2,1-b]thiazol-3-yl) acetamide (5a), and tested for their cytotoxicity against human cancer cell lines, including HepG2 and MDA-MB-231. The results indicated that the compound 2-(6-(4-chlorophenyl)imidazo [2,1-b]thiazol-3-yl)-N-(6-(4-(4-methoxybenzyl) piperazin-1-yl)pyridin-3-yl)acetamide (5l), with slightly higher inhibition on VEGFR2 than 5a (5.72% and 3.76% inhibitory rate at 20 μM, respectively), was a potential inhibitor against MDA-MB-231 (IC50 = 1.4 μM) compared with sorafenib (IC50 = 5.2 μM), and showed more selectivity against MDA-MB-231 than HepG2 cell line (IC50 = 22.6 μM).