57666-50-9

Basic information

• Product Name: 2-Furancarbonitrile, 5-phenyl-
• CAS NO: 57666-50-9
• Molecular Formula: C11H7NO
• Molecular Weight: 169.183
• Mol File: 57666-50-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Furancarbonitrile, 5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Furancarbonitrile, 5-phenyl-(57666-50-9)
• EPA Substance Registry System: 2-Furancarbonitrile, 5-phenyl-(57666-50-9)

Safety Data

• Hazardous Substances Data: 57666-50-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 13803-39-9 5-phenylfuran-2-carbaldehyde 
• 17113-33-6 2-phenylfuran 
• 506-68-3 bromocyane 
• 13803-16-2 5-phenylfuran-2-carboxaldehyde oxime 
• 63191-69-5 5-phenyl-furan-2-carbaldehyde oxime 

Downstream Products

• 59589-50-3 O-methyl-5-phenyl-2-furamidoxime 
• 62821-37-8 2-(5-phenyl-furan-2-yl)imidazole hydrochloride 
• 350692-01-2 N¹-Acetyl-N¹-(5-phenyl-2-furyl)-N²-phenylurea 
• 350691-65-5 N²-Phenyl-5-phenylfuran-2-carboximidamide 
• 60838-09-7 5-(5-phenyl-furan-2-yl)-1⁽²⁾H-tetrazole 

Relevant articles and documents

Alkali α-MnO2/Na: XMnO2 collaboratively catalyzed ammoxidation-Pinner tandem reaction of aldehydes

The tandem reaction is a growing field to yield important advances toward green and sustainable chemistry. Herein, we report a bifunctional manganese oxide catalyst with an interface binding redox phase (α-MnO2) and a basic phase (NaxMnO2). The molar ratio of NaOH/Mn plays a great role in the formation of α-MnO2/NaxMnO2. The sodium cation is essential for the formation of a basic NaxMnO2 phase while the potassium cation promotes the formation of a redox-active α-MnO2 phase. The interface structure of α-MnO2/NaxMnO2 geometrically favors the ammoxidation-Pinner tandem reaction to synthesize imidates in a 58-96% yield from aldehydes. Thus a phase collaborative effect is observed. In the ammoxidation process, the redox cycle of MnIV/MnIII is involved and the lattice oxygen in the α-MnO2 phase acts as an active oxygen species. The O-H in methanol is activated and dissociated on the basic sites of NaxMnO2 to the adsorbed methoxyl species to facilitate the Pinner synthesis. This approach bypasses the conventional synthesis of imidates, which suffer from harsh reaction conditions and the requirement for multiple steps.

A simple method for the synthesis of 5-substituted 2-cyanofurans

A new method based on the Schmidt reaction was developed for the production of 5-R-2-cyanofurans from 5-R-furfurals.

SYNTHESIS OF 5-SUBSTITUTED CYANOFURANS AND THEIR REACTION WITH HYDRAZINE

Based on the Schmidt reaction, a new method has been developed for the preparation of nitriles in furan series from the corresponding furfural derivatives.Depending on conditions, the reaction of 5-substituted cyanofurans with hydrazine leads to amidrazones, N-aminotriazoles, or 1,2,4,5-dihydrotetrazines.